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Treatment of hairy-cell leukemia.

Author: GoldeD W, LillM C

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Treatment for hairy-cell leukemia has significantly improved with the introduction of interferon alpha, deoxycoformycin, and chlorodeoxyadenosine. While a standard treatment protocol has not been established, an individualized approach is recommended, with splenectomy potentially beneficial for patients with low bone marrow involvement and cytopenia. Interferon alpha is currently the preferred first-line drug treatment, while deoxycoformycin remains experimental due to long-term toxicity concerns. Chlorodeoxyadenosine shows promise but needs further evaluation. Intensive chemotherapy and alkylating agents are generally not used in modern treatment.
Paper Details　
Original Abstract of the Article :
Hairy-cell leukemia is an unusual chronic lymphoid leukemia with distinctive clinical and pathological features. The management of this disorder has been revolutionized in the last decade with the discovery of the efficacy of alpha interferon and the inhibitors of adenosine metabolism, deoxycoformyc...See full text at original site
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引用元：
https://doi.org/10.1016/0268-960x(90)90003-b

データ提供：米国国立医学図書館（NLM）

Revolutionizing Hairy-Cell Leukemia Treatment: A Look at Novel Therapies

This research explores the advancements in the treatment of hairy-cell leukemia, a rare form of chronic leukemia. The author highlights the revolutionary impact of alpha interferon and inhibitors of adenosine metabolism, deoxycoformycin and chlorodeoxyadenosine, on the management of this disease. While significant progress has been made, the author emphasizes that the optimal treatment protocol remains undefined, and further research is crucial to address long-term toxicity concerns associated with these novel therapies. This study underscores the ongoing quest for more effective and safe treatment options for patients with hairy-cell leukemia.

New Therapies Offer Hope for Hairy-Cell Leukemia Patients

The study highlights the positive impact of novel therapies on the treatment of hairy-cell leukemia. The author emphasizes the importance of individualized treatment approaches, tailoring therapy to the specific needs of each patient. The research also underscores the need for ongoing research to refine existing therapies and explore new treatment options to further improve patient outcomes.

Navigating the Treatment Landscape for Hairy-Cell Leukemia

This research provides valuable insights into the evolving landscape of hairy-cell leukemia treatment. It highlights the crucial role of ongoing research and clinical trials in developing safer and more effective therapies. The study encourages patients with hairy-cell leukemia to seek out specialists and participate in clinical trials to access the latest treatment options and contribute to advancing knowledge in this field.

Dr.Camel's Conclusion

The quest for effective treatment for hairy-cell leukemia is like a caravan searching for a hidden oasis in the vast desert. This research, like a guiding star, illuminates the path towards new and promising therapies. It's a reminder that even the most challenging medical journeys can be navigated with perseverance and innovation, offering hope to those seeking a cure.

Date :
  1. Date Completed 1991-04-22
  2. Date Revised 2019-10-28
Further Info :

Pubmed ID

1706207

DOI: Digital Object Identifier

10.1016/0268-960x(90)90003-b

SNS
PICO Info
in preparation
Languages

English

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