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Effects of PKC412, nilotinib, and imatinib against GIST-associated PDGFRA mutants with differential imatinib sensitivity.

Author: CatleyLaurie, FabbroDoriano, GriffinJames D, Hall-MeyersElizabeth, JiangJingrui, KungAndrew L, ManleyPaul W, MorenoDaisy, PodarKlaus, RayArghya, WeisbergEllen, WrightRenee D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effects of three tyrosine kinase inhibitors, PKC412, nilotinib, and imatinib, on two PDGFRA mutants, V561D and D842V, which exhibit differential sensitivity to imatinib.
Paper Details　
Original Abstract of the Article :
Activating mutations in platelet-derived growth factor receptor alpha (PDGFRA) have been reported in a subset of gastrointestinal stromal tumor (GIST) patients who do not express the mutant stem cell factor receptor c-kit. The responsiveness of mutant PDGFRA-positive GIST to imatinib depends on the ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/17087936

データ提供：米国国立医学図書館（NLM）

Targeted Therapy: New Hope for GIST Patients

Gastrointestinal stromal tumors (GISTs) are a type of cancer that affects the digestive system. This research investigated the effectiveness of three tyrosine kinase inhibitors – PKC412, nilotinib, and imatinib – in treating GISTs with specific mutations in the PDGFRA gene. The study compared the effects of these drugs on two GIST-associated PDGFRA mutants, V561D and D842V, which exhibit different sensitivities to imatinib. The study found that PKC412 and nilotinib were more effective in inhibiting the growth of GIST cells with the D842V mutation, which is typically resistant to imatinib.

Personalized Medicine: Tailoring Treatment to Individual Needs

This research highlights the importance of personalized medicine, where treatment strategies are tailored to the specific genetic characteristics of a patient's tumor.

Hope for a Cure: Advances in Cancer Treatment

This research showcases the progress being made in developing targeted therapies for cancer, offering new hope for patients.

Dr.Camel's Conclusion

This research is like a treasure hunt in the vast desert of cancer research, uncovering new and effective treatments for GISTs.

Date :
  1. Date Completed 2007-01-30
  2. Date Revised 2022-01-14
Further Info :

Pubmed ID

17087936

DOI: Digital Object Identifier

NIHMS23357

Related Literature

Article Analysis
・Effects of nilotinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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