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Effectiveness of ciclesonide nasal spray in the treatment of seasonal allergic rhinitis.

Author: BrookmanSheldon, DarkenPatrick F, HampelFrank, HellbardtStefan, RatnerPaul H, ShahTushar, WingertzahnMark A, van BavelJulius H

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the anti-inflammatory activity of ciclesonide, an investigational corticosteroid for the treatment of allergic rhinitis. Ciclesonide is converted to its active metabolite, desisobutyryl-ciclesonide (des-CIC), which has a long duration of anti-inflammatory activity in human nasal and bronchial epithelial cells.
Paper Details　
Original Abstract of the Article :
Ciclesonide is an investigational corticosteroid under development for treatment of allergic rhinitis. Ciclesonide is converted to active metabolite, desisobutyryl-ciclesonide (des-CIC), by upper and lower airway esterases. In vitro studies in human nasal epithelial cells and bronchial epithelial ce...See full text at original site
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引用元：
https://doi.org/10.1016/S1081-1206(10)61097-6

データ提供：米国国立医学図書館（NLM）

Ciclesonide Nasal Spray: A Potential Oasis in the Desert of Seasonal Allergic Rhinitis

Seasonal allergic rhinitis (SAR), a common condition affecting millions, can significantly impact quality of life. This study, like a traveler seeking relief from the harsh desert sun, investigates the potential of ciclesonide nasal spray as a treatment for SAR. The researchers explored the effectiveness of ciclesonide, a corticosteroid, in alleviating symptoms of SAR.

Navigating the Desert of SAR: The Promise of Ciclesonide

The study highlights the potential of ciclesonide as a treatment for SAR, emphasizing its long-lasting anti-inflammatory activity. The researchers observed that ciclesonide, upon conversion to its active metabolite, desisobutyryl-ciclesonide (des-CIC), effectively reduces inflammation in the nasal passages, offering potential relief from symptoms of SAR.

Finding Relief in the Desert of Allergic Reactions: Exploring Treatment Options

This study provides valuable insights into the potential of ciclesonide nasal spray as a treatment for SAR. It suggests that ciclesonide, through its conversion to des-CIC, may offer a promising approach to managing SAR symptoms and improving the quality of life for individuals suffering from this condition.

Dr. Camel's Conclusion

The desert of allergies can be a harsh and unforgiving environment, but this study offers hope for individuals seeking relief from SAR. Ciclesonide nasal spray, with its potential for long-lasting anti-inflammatory activity, may provide a valuable tool for managing symptoms and improving quality of life. As healthcare professionals, we must continue to explore new treatment options, like ciclesonide, to help individuals navigate the challenges of allergies and find their oasis of relief.

Date :
  1. Date Completed 2007-01-17
  2. Date Revised 2013-05-30
Further Info :

Pubmed ID

17165276

DOI: Digital Object Identifier

10.1016/S1081-1206(10)61097-6

Related Literature

Article Analysis
・Effects of ciclesonide nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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