Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND).

Author: LyonM, MillerR G, MitchellJ D, MooreD H

Paper Details 
Original Abstract of the Article :
BACKGROUND: Riluzole has been approved for treatment of patients with amyotrophic lateral sclerosis in most countries. Questions persist about its clinical utility because of high cost and modest efficacy. OBJECTIVES: To examine the efficacy of riluzole in prolonging survival, and in delaying the u...See full text at original site
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引用元:
https://doi.org/10.1002/14651858.CD001447.pub2

データ提供:米国国立医学図書館(NLM)

Riluzole for Amyotrophic Lateral Sclerosis (ALS)/Motor Neuron Disease (MND)

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND), is a devastating neurodegenerative disease. This research examines the efficacy of riluzole in treating ALS, using a systematic review approach to analyze existing data. The authors investigated the effectiveness of riluzole in prolonging survival and delaying the use of life-sustaining interventions, finding that riluzole 100 mg daily is reasonably safe and probably prolongs median survival by about two to three months in patients with ALS.

Riluzole: A Potential Treatment for ALS

The study's findings suggest that riluzole, a medication approved for the treatment of ALS, may have a modest but significant effect in prolonging survival. The analysis of four randomized trials indicated a benefit for the homogeneous group of patients in the first two trials, with riluzole 100 mg per day providing a 9% gain in the probability of surviving one year. These findings provide evidence supporting the use of riluzole as a potential treatment option for ALS.

Living with ALS: Managing Symptoms and Prolonging Life

ALS is a complex and challenging disease, and managing symptoms and prolonging life are crucial aspects of patient care. This research highlights the potential of riluzole, a medication that can slow the progression of ALS, to improve the quality of life and extend survival for patients with this debilitating disease. The study underscores the need for continued research and development of effective therapies for ALS.

Dr. Camel's Conclusion

ALS, like a relentless desert storm, can be devastating. Riluzole, like a sturdy camel saddle, can help to manage the journey, providing a measure of comfort and extending the time spent on this challenging path. This research highlights the importance of seeking treatment and finding ways to live with ALS as effectively as possible.

Date :
  1. Date Completed 2007-05-08
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

17253460

DOI: Digital Object Identifier

10.1002/14651858.CD001447.pub2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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