Randomized study comparing cyclosporine with azathioprine one year after renal transplantation-15-year outcome data.

Author: JossNicola, JunorBrian J, McMillanMargaret A, RodgerR Stuart

Paper Details 
Original Abstract of the Article :
The introduction of cyclosporine (CsA) improved 1-year graft survival and reduced the incidence of acute rejection episodes after renal transplantation compared to azathioprine (Aza). However, CsA has many side effects and reducing exposure of this drug after the first year may benefit long-term pat...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/17353778

データ提供:米国国立医学図書館(NLM)

Long-term Outcomes of Cyclosporine vs. Azathioprine in Kidney Transplantation

The field of transplantation medicine is a fascinating oasis in the vast desert of healthcare. This study delves into the long-term outcomes of two common immunosuppressant drugs, cyclosporine (CsA) and azathioprine (Aza), used after kidney transplantation. The authors compare the 15-year outcomes of patients who received either drug, revealing insights into their long-term efficacy and safety.

Cyclosporine: A Double-Edged Sword

Cyclosporine initially revolutionized transplantation, improving graft survival and reducing rejection episodes. However, its long-term use can lead to various side effects, highlighting the need for careful management. Like a desert mirage, cyclosporine initially appears promising, but its long-term effects must be carefully considered.

Balancing Immunosuppression and Patient Health

This study emphasizes the importance of individualized treatment plans. Just as a desert traveler needs to adapt their journey to the changing landscape, transplant patients require a tailored approach to manage immunosuppression while minimizing the risk of side effects. Understanding the long-term consequences of these drugs allows for better patient care and improved outcomes.

Dr.Camel's Conclusion

This research highlights the ongoing quest for optimal immunosuppressive strategies in transplantation. Finding the right balance between preventing rejection and minimizing side effects is a constant challenge, akin to navigating a winding desert path. Long-term studies, like this one, provide crucial insights that guide our efforts towards better patient care in this complex field.

Date :
  1. Date Completed 2007-04-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17353778

DOI: Digital Object Identifier

00007890-200703150-00012

SNS
PICO Info
in preparation
Languages

English

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