Safety and efficacy of bortezomib in high-risk and elderly patients with relapsed multiple myeloma.

Author: AndersonKenneth C, Ben-YehudaDina, CavenaghJamie D, FaconThierry, HarousseauJean-Luc, IrwinDavid, LonialSagar, RichardsonPaul G, San MiguelJesús-F, SchusterMichael W, SonneveldPieter, StadtmauerEdward A

Paper Details 
Original Abstract of the Article :
Adverse prognostic factors in multiple myeloma include advanced age, number of prior therapies, and higher International Staging System (ISS) disease stage. In the international, randomised, phase-3 Assessment of Proteasome Inhibition for Extending Remissions (APEX) study, bortezomib demonstrated si...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2141.2007.06585.x

データ提供:米国国立医学図書館(NLM)

Bortezomib: A Powerful Weapon Against Relapsed Multiple Myeloma

This study examines the safety and efficacy of bortezomib in treating relapsed multiple myeloma, focusing on high-risk and elderly patients. The authors analyze data from the APEX study, which compared bortezomib to high-dose dexamethasone in patients with relapsed multiple myeloma. The study found that bortezomib demonstrated significantly longer time to progression, higher response rates, and improved survival compared to dexamethasone, even in high-risk and elderly subgroups. While bortezomib was associated with higher rates of grade 3/4 adverse events, these were generally manageable, and the overall safety profile was favorable. The study concludes that bortezomib should be considered an appropriate treatment option for elderly and high-risk patients with relapsed multiple myeloma.

Bortezomib: A Beacon of Hope for Multiple Myeloma Patients

The study's findings offer a beacon of hope for individuals battling relapsed multiple myeloma, particularly those facing challenging prognostic factors. Bortezomib, like a sturdy camel navigating a treacherous desert, effectively combats myeloma, even in high-risk populations. The study's comprehensive analysis of bortezomib's efficacy and safety profile provides strong evidence for its potential to improve patient outcomes and extend survival.

Multiple Myeloma: A Complex and Challenging Disease

The study highlights the complexity of multiple myeloma, a challenging cancer that requires effective treatments to manage disease progression and improve patient quality of life. Multiple myeloma, like a shifting desert landscape, can be difficult to navigate, but the study's findings offer a potentially valuable tool for managing this complex disease. The study's emphasis on patient well-being, alongside efficacy, underscores the importance of considering not just the effectiveness of a treatment but also its impact on the patient's overall quality of life.

Dr.Camel's Conclusion

This study explores the safety and efficacy of bortezomib in treating relapsed multiple myeloma, particularly in high-risk and elderly patients. The study's findings, like a clear path through a challenging desert, offer hope for individuals battling this complex cancer. The study's insights into bortezomib's efficacy and safety profile provide valuable information for clinicians, empowering them to make informed decisions about treatment options for their patients.
Date :
  1. Date Completed 2007-06-28
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

17451408

DOI: Digital Object Identifier

10.1111/j.1365-2141.2007.06585.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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