Paper Details

  1. Home
  2. Paper Details

Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics.

Author: EdickMathew J, EvansWilliam E, GrosveldGerard, HartfordChristine, PuiChing-Hon, RehgJerold E, RellingMary V, SchwabMatthias, VasquezErick

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of the thiopurine methyltransferase (TPMT) polymorphism on the pharmacokinetics and pharmacodynamics of mercaptopurine and thioguanine in a murine knockout model. The study found that the TPMT polymorphism significantly affects the metabolism of both drugs, with mercaptopurine being more sensitive than thioguanine. The results suggest that the TPMT polymorphism needs to be considered in optimizing drug therapy for individuals receiving thiopurine-based medications.
Paper Details　
Original Abstract of the Article :
The recessive deficiency in thiopurine methyltransferase (TPMT), caused by germ-line polymorphisms in TPMT, can cause severe toxicity after mercaptopurine. However, the significance of heterozygosity and the effect of the polymorphism on thioguanine or in the absence of thiopurines is not known. To ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1158/0008-5472.CAN-06-3508

データ提供：米国国立医学図書館（NLM）

Unveiling the Mystery of Thiopurine Methyltransferase: A Tale of Genetic Variations and Drug Effects

In the realm of personalized medicine, understanding genetic variations and their impact on drug responses is paramount. This research delves into the complexities of thiopurine methyltransferase (TPMT), an enzyme involved in the metabolism of thiopurine drugs. The study focuses on the impact of TPMT deficiency, caused by germ-line polymorphisms in the TPMT gene, on the pharmacodynamics of mercaptopurine and thioguanine. The researchers created a murine knockout of Tpmt and conducted pharmacokinetic and pharmacodynamic studies in Tpmt(-/-), Tpmt(+/-), and Tpmt(+/+) mice. They discovered that TPMT deficiency significantly altered the metabolism of both mercaptopurine and thioguanine, leading to differences in drug toxicity and efficacy.

The Influence of Genetics on Drug Response: A Lesson from Mice

This study reveals the critical role of genetics in shaping individual responses to medication. The researchers found that Tpmt knockout mice exhibited significantly different responses to mercaptopurine and thioguanine compared to wild-type mice. These findings highlight the importance of considering individual genetic variations when prescribing medication, ensuring optimal treatment outcomes and minimizing the risk of adverse effects.

A Personalized Approach to Medication: Tailoring Treatment to Individual Needs

This research underscores the need for a personalized approach to medication. The study's findings emphasize the importance of understanding individual genetic variations and their impact on drug metabolism. By considering these genetic differences, healthcare professionals can optimize treatment plans, ensuring that patients receive the appropriate dose of medication and minimize the risk of adverse effects.

Dr.Camel's Conclusion

Just as a camel's ability to navigate a desert depends on its unique adaptations, our bodies respond to medication in ways that are influenced by our individual genetic makeup. This research shines a light on the importance of considering genetic variations when prescribing medication, paving the way for a more personalized and effective approach to healthcare.

Date :
  1. Date Completed 2007-07-03
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

17510427

DOI: Digital Object Identifier

10.1158/0008-5472.CAN-06-3508

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.