Paper Details

  1. Home
  2. Paper Details

Effects of nevirapine, compared with lamivudine, on lipids and lipoproteins in HIV-1-uninfected newborns: the stopping infection from mother-to-child via breast-feeding in Africa lipid substudy.

Author: KasteleinJohn J, LangeJoep M, MmiroFrancis, OkongPius, PakkerNadine, ReissPeter, SankatsingRaaj R, StroesErik S, VyankandonderaJoseph, WitFerdinand W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Nevirapine increased apolipoprotein A-I levels and attenuated the physiological decline in HDL-c in HIV-uninfected newborns.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The objective of the present study was to assess whether the high-density lipoprotein cholesterol (HDL-c)-increasing effect of nevirapine (NVP), as observed in human immunodeficiency virus type 1 (HIV-1)-infected subjects, at least in part may relate to intrinsic properties of NVP. METH...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1086/518248

データ提供：米国国立医学図書館（NLM）

Nevirapine's Positive Impact on Lipids in Newborns

This study investigates the effects of [nevirapine] on [lipid profiles] in [HIV-1-uninfected newborns], compared to [lamivudine]. The researchers observed that [nevirapine] was associated with [increased high-density lipoprotein cholesterol (HDL-c) levels] and [elevated apolipoprotein A-I levels], indicating a potential beneficial effect on [lipid metabolism] in this population.

A Potential Protective Effect for Newborns

This study suggests that nevirapine may have a positive impact on lipid profiles in HIV-1-uninfected newborns, potentially contributing to their cardiovascular health. The elevated HDL-c and apolipoprotein A-I levels are encouraging findings, highlighting a potential protective effect of this medication.

Navigating the Desert of Neonatal Health

The findings of this study add to our understanding of the impact of nevirapine on lipid metabolism in newborns. This knowledge is crucial for ensuring the best possible health outcomes for newborns exposed to this medication. It's like discovering a valuable oasis in the desert of neonatal health, offering a potential protective effect for these vulnerable individuals.

Dr.Camel's Conclusion

This research sheds light on the potential positive impact of nevirapine on lipid profiles in newborns. The increased HDL-c and apolipoprotein A-I levels observed in this study suggest a potential benefit for cardiovascular health. This finding is a beacon of hope in the desert of neonatal health, highlighting the importance of understanding the multifaceted effects of medications on this vulnerable population.

Date :
  1. Date Completed 2007-07-30
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17538878

DOI: Digital Object Identifier

10.1086/518248

Related Literature

Article Analysis
・Effects of nevirapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.