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Indinavir/low-dose ritonavir containing HAART in HIV-1 infected children has potent antiretroviral activity, but is associated with side effects and frequent discontinuation of treatment.

Author: BurgerD M, FraaijP L A, HartwigN G, VerweelG, de GrootR, van RossumA M C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Indinavir plus low-dose ritonavir and two nucleoside reverse transcriptase inhibitors (NRTIs) were effective in controlling HIV-1 infection in children. However, this regimen was associated with side effects and therapy discontinuation.
Paper Details　
Original Abstract of the Article :
We here present the study results of 21 HIV-1 infected children who were treated with indinavir plus low-dose ritonavir and two nucleoside reverse transcriptase inhibitors (NRTIs) for 48 weeks. Although this q12h HAART regimen had potent antiretroviral activity, it was frequently associated with sid...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782124/

データ提供：米国国立医学図書館（NLM）

The Balancing Act of HIV Treatment: A Study of Indinavir/Low-Dose Ritonavir in Children

Imagine a delicate dance, where every step must be precise and carefully choreographed. This research explores the challenges of treating HIV infection in children, focusing on the use of a specific drug regimen – indinavir plus low-dose ritonavir combined with nucleoside reverse transcriptase inhibitors. The study examines the effectiveness of this regimen, but also highlights the potential side effects and challenges associated with its use.

A Complex Dance of Treatment: Exploring the Effectiveness and Side Effects of Indinavir/Low-Dose Ritonavir

The study, like a choreographer meticulously refining a dance routine, analyzed data from 21 HIV-infected children who received this drug regimen for 48 weeks. The findings revealed that the regimen had potent antiretroviral activity, effectively reducing the levels of the virus. However, the researchers also noted that the regimen was often associated with side effects and frequent treatment discontinuation, underscoring the need for careful monitoring and management in pediatric patients.

The Importance of Personalized Care: Finding the Right Balance for Each Child

The researchers emphasize the need for individualized treatment approaches, taking into account each child's specific needs and risk factors. Just as every dancer has their own unique strengths and limitations, so too do children with HIV require tailored treatment strategies. The study highlights the importance of balancing therapeutic efficacy with the potential for adverse events, ensuring that treatment is both effective and safe for young patients.

Dr. Camel's Conclusion

This research reminds us that the path to effective HIV treatment for children is a winding one, demanding careful consideration of individual needs and potential challenges. The study serves as a reminder to embrace individualized approaches, recognizing the unique complexities of each patient's journey. Like a patient camel crossing a vast desert, each child requires careful guidance and support to reach their destination.

Date :
  1. Date Completed 2007-10-16
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

17565462

DOI: Digital Object Identifier

PMC2782124

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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