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Clinical experience with pamidronate in the treatment of Paget's disease of bone.

Author: BoyceB F, BoyleI T, GallacherS J, JenkinsA, PatelU, RalstonS H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study examined the effectiveness of pamidronate in treating Paget's disease of bone in 39 patients. Two treatment groups received pamidronate infusions: group 1 received weekly infusions for 6 weeks, with a subgroup receiving higher doses for 3 weeks, and group 2 received infusions every 3 months for a year. Both groups showed significant decreases in serum alkaline phosphatase (ALP) levels, a marker of bone turnover, throughout the year. While group 1 achieved lower ALP levels, with some patients reaching normal levels, group 2 showed sustained improvement in ALP levels after 3 months. The study concluded that pamidronate is an effective treatment for Paget's disease, with a convenient regimen of 45mg every 3 months for patients with moderate ALP levels, and potentially higher doses for patients with higher ALP levels.
Paper Details　
Original Abstract of the Article :
Bisphosphonates have been shown to be effective in treating the increased bone turnover associated with Paget's disease of bone. In this study two groups of patients were treated with pamidronate by intravenous infusion. In group 1 (n = 15) 30 mg of pamidronate was given once a week for six weeks. A...See full text at original site
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引用元：
https://doi.org/10.1136/ard.50.12.930

データ提供：米国国立医学図書館（NLM）

Pamidronate: A Powerful Tool in the Treatment of Paget's Disease

This study examines the efficacy of pamidronate, a bisphosphonate medication, in treating Paget's disease of bone. It's like finding a hidden oasis in the desert, offering a solution to a debilitating and painful condition. The study found that pamidronate effectively reduced bone turnover and serum alkaline phosphatase levels in patients with Paget's disease. This study provides valuable insights into the use of pamidronate in the management of this bone disorder.

A New Era in Paget's Disease Treatment

This study highlights the effectiveness of pamidronate in treating Paget's disease of bone. It's like discovering a new well in a parched desert, offering relief and a chance for healing. The study found that pamidronate significantly reduced bone turnover and serum alkaline phosphatase levels, demonstrating its potential to improve the lives of patients with this condition.

Hope for Patients with Paget's Disease

This research provides hope for patients with Paget's disease, highlighting the potential for effective treatment with pamidronate. It's a reminder that even challenging medical conditions can be managed and treated with advancements in medical research. This study underscores the importance of continuous research and innovation in finding solutions for debilitating diseases.

Dr.Camel's Conclusion

This study showcases the power of medical research in finding effective treatments for debilitating conditions. It's like discovering a hidden oasis in the desert of medical knowledge, offering relief and hope for patients suffering from Paget's disease. This research reminds us that with continuous exploration and innovation, we can find solutions for even the most challenging medical problems.

Date :
  1. Date Completed 1992-02-20
  2. Date Revised 2019-05-03
Further Info :

Pubmed ID

1768163

DOI: Digital Object Identifier

10.1136/ard.50.12.930

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Article Analysis
・Effective treatment of paget's disease of bone
SNS
PICO Info
in preparation
Languages

English

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