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Cefixime shows good effects on group A and group B beta-haemolytic streptococci.

Author: BerlinghieriM C, CarboneM, CasiniA, De LucaM, FeraM T, FocàA, LibertoM C, PuccioR

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cefixime, a new orally active cephalosporin, has a broad spectrum of antibacterial activity against a variety of bacteria, including Enterobacteriaceae, Haemophilus influenzae, Branhamella catarrhalis, Streptococcus pneumoniae, and Streptococcus pyogenes. This study investigated the effects of cefixime on Group A and Group B beta-haemolytic streptococci. The results show that cefixime significantly reduced the adherence of Group A streptococci to buccal cells, and 86.1% of strains showed an MIC less than or equal to 0.5 microgram/ml. Growth curves demonstrated a bactericidal effect after 3 hours. 70.3% of Group B streptococci strains exhibited an MIC less than or equal to 2 micrograms/ml. Cefixime shows good activity against beta-haemolytic streptococci, particularly Group A.
Paper Details　
Original Abstract of the Article :
There is continued interest in the development of oral beta-lactam compounds, which can be used clinically to treat various bacterial infections, particularly those caused by beta-haemolytic streptococci. Cefixime is a new orally active cephalosporin, with a broad spectrum of antibacterial activity,...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1769318

データ提供：米国国立医学図書館（NLM）

Cefixime: A Promising Antibiotic for Beta-Hemolytic Streptococci

The world of medicine is constantly on the lookout for new and effective ways to combat bacterial infections, especially those caused by notorious culprits like beta-hemolytic streptococci. This research delves into the potential of cefixime, a new cephalosporin antibiotic, as a weapon against these troublesome bacteria.

The researchers employed a scientific approach, evaluating the minimum inhibitory concentrations (MICs) of cefixime and its effects on the growth and adherence of Group A and Group B beta-hemolytic streptococci. They discovered that cefixime displayed a remarkable ability to inhibit the growth of these bacteria, with a significant percentage of strains showing sensitivity to the drug. Furthermore, cefixime demonstrated a unique ability to disrupt the adherence of these bacteria to buccal cells, potentially preventing the colonization and spread of infection.

Cefixime’s Bactericidal Action: A New Hope for Treatment

The findings suggest that cefixime possesses a bactericidal effect, meaning it can kill the bacteria outright, as opposed to simply slowing their growth. This potent action makes cefixime a promising candidate for the treatment of infections caused by beta-hemolytic streptococci.

Implications for Infection Control and Treatment

The study sheds light on the potential of cefixime as a valuable tool for combating infections caused by beta-hemolytic streptococci. Its bactericidal activity and ability to hinder bacterial adherence suggest that it could offer a new avenue for effective treatment and prevention of these infections.

Dr. Camel's Conclusion

This study is like a refreshing oasis in the dry, vast desert of bacterial infections. Cefixime, with its bactericidal action and ability to disrupt bacterial adherence, is a beacon of hope for those seeking relief from these pesky infections. However, like a sandstorm, further research is needed to fully understand the potential of this antibiotic and its long-term effects.

Date :
  1. Date Completed 1992-02-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1769318

DOI: Digital Object Identifier

1769318

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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