A bifunctional colchicinoid that binds to the androgen receptor.

Author: DaltonJames T, FarrarWilliam L, HamelErnest, HossainMd Tafazzal, JonesAmanda, KaneCharles T, LillMarkus A, RisboodPrabhakar, SharifiNima

Paper Details 
Original Abstract of the Article :
Castrate-resistant prostate cancer (CRPC) continues to be dependent on the androgen receptor (AR) for disease progression. We have synthesized and evaluated a novel compound that is a conjugate of colchicine and an AR antagonist (cyanonilutamide) designed to inhibit AR function in CRPC. A problem in...See full text at original site
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引用元:
https://doi.org/10.1158/1535-7163.MCT-07-0163

データ提供:米国国立医学図書館(NLM)

Targeting Prostate Cancer: A Bifunctional Colchicinoid for AR Inhibition

Prostate cancer, a common form of cancer in men, can be a challenging adversary. It's like a tenacious desert weed, difficult to eradicate. This article delves into the world of prostate cancer treatment, focusing on a novel compound designed to combat castrate-resistant prostate cancer (CRPC). The researchers have synthesized a compound that combines two powerful elements – colchicine and an androgen receptor (AR) antagonist – to inhibit the growth of CRPC. The compound exhibits promising properties, effectively binding to both the AR and tubulin, effectively disrupting the cancer cells' growth and survival. This study offers a potential new weapon in the fight against prostate cancer, providing hope for patients facing this challenging condition.

A New Weapon in the Desert: A Bifunctional Colchicinoid for Prostate Cancer

This study provides a glimpse of hope in the fight against prostate cancer. The novel compound, combining the powers of colchicine and an AR antagonist, shows promise in inhibiting the growth of CRPC. It's like finding a new weapon in the desert – a tool to help combat the tenacious weed of prostate cancer. This study opens up new avenues for treatment and offers a potential lifeline for patients facing this challenging disease.

Fighting the Desert Weed: New Strategies for Prostate Cancer

Prostate cancer can be a challenging condition, but researchers are constantly seeking new ways to combat it. This study offers a potential breakthrough, highlighting a novel compound that effectively targets the androgen receptor and tubulin, key players in CRPC growth. It's like finding a new strategy for controlling the tenacious desert weed – a weapon to help fight back against this challenging condition.

Dr. Camel's Conclusion

This study provides a promising glimpse into the future of prostate cancer treatment. The novel bifunctional colchicinoid, like a camel navigating a vast and challenging desert, offers a potential solution for combating CRPC. It's a beacon of hope for patients facing this difficult condition.

Date :
  1. Date Completed 2007-10-15
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

17699728

DOI: Digital Object Identifier

10.1158/1535-7163.MCT-07-0163

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English

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