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Emerging drugs for hyperphosphatemia.

Author: BellinghieriGuido, SantoroDomenico, SavicaVincenzo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Hyperphosphatemia is a major risk factor for cardiovascular mortality in dialysis patients. While aluminum-based phosphate binders have side effects, calcium-based binders can worsen calcification. New non-aluminum and non-calcium binders like sevelamer and lanthanum carbonate show promise, but long-term studies are needed. The possibility of salivary phosphate binders is being explored to reduce phosphate absorption.
Paper Details　
Original Abstract of the Article :
Cardiovascular mortality is the leading cause of death in the uremic patient. Hyperphosphatemia is considered an independent risk factor associated with cardiovascular morbidity and mortality in dialysis patients. As phosphate control is not efficient with diet or dialysis, phosphate binders are com...See full text at original site
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引用元：
https://doi.org/10.1517/14728214.12.3.355

データ提供：米国国立医学図書館（NLM）

Hyperphosphatemia: A Silent Threat in Chronic Kidney Disease

Chronic kidney disease, like a relentless desert wind, can cause a buildup of phosphate in the blood, a condition known as hyperphosphatemia. This condition is a significant risk factor for cardiovascular disease, a major cause of death in individuals with kidney failure. This study explored the challenges of managing hyperphosphatemia in dialysis patients, individuals who rely on dialysis to filter their blood. The researchers reviewed current treatments for hyperphosphatemia, including phosphate binders, medications designed to bind phosphate in the digestive tract, and discussed the limitations of these therapies. They also introduced new phosphate binders, sevelamer hydrochloride and lanthanum carbonate, which have shown promising results in controlling phosphate levels and reducing the risk of cardiovascular complications.

The Takeaway: New Phosphate Binders Offer Hope for Hyperphosphatemia

This study highlights the importance of managing hyperphosphatemia in individuals with chronic kidney disease and suggests that new phosphate binders, such as sevelamer hydrochloride and lanthanum carbonate, may offer a better approach to controlling phosphate levels and reducing cardiovascular risks.

The Impact on Your Health: Living with Chronic Kidney Disease

If you are living with chronic kidney disease, it's crucial to work closely with your healthcare provider. They can monitor your phosphate levels, recommend appropriate treatment options, and provide guidance on lifestyle modifications to manage your condition. Remember, early detection and intervention are key to preventing complications and improving your overall health.

Dr. Camel's Conclusion

This study underscores the need for ongoing research and innovation in managing chronic kidney disease. The development of new phosphate binders offers a glimmer of hope for individuals facing the challenges of hyperphosphatemia. As researchers, we strive to find new oases in the desert of chronic illness, offering better treatments and improving the lives of those affected.

Date :
  1. Date Completed 2007-09-27
  2. Date Revised 2019-11-10
Further Info :

Pubmed ID

17874966

DOI: Digital Object Identifier

10.1517/14728214.12.3.355

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Languages

English

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