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Inhibition of human aromatase complex (CYP19) by antiepileptic drugs.

Author: BirkvedF K, Halling-SørensenB, JacobsenN W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Twelve antiepileptic drugs were tested for their ability to inhibit aromatase, an enzyme crucial for estrogen synthesis. Lamotrigine, oxcarbazepine, tiagabine, phenobarbital, phenytoin, ethosuximide, and valproate showed inhibition, highlighting potential side effects on steroid synthesis in humans.
Paper Details　
Original Abstract of the Article :
Antiepileptic drugs and epilepsy are often associated with sexual disorder in women such as hyperandrogenism, menstrual disorders and ovarian cysts. In children, until puberty, a hormone imbalance may influence many aspects of development, e.g. growth and sexual maturation. The aromatase complex is ...See full text at original site
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引用元：
https://doi.org/10.1016/j.tiv.2007.09.004

データ提供：米国国立医学図書館（NLM）

The Impact of Antiepileptic Drugs on Hormone Balance

The field of [epilepsy treatment] is constantly evolving, seeking to develop [effective and well-tolerated] medications. This study examined the [inhibitory effects of antiepileptic drugs (AEDs)] on the [aromatase complex (CYP19)], an enzyme responsible for converting [androgens to estrogens]. The researchers aimed to understand how these drugs might impact [hormonal balance] and potentially lead to [sexual disorders] in [women and children].

AEDs and Hormone Imbalance: A Complex Relationship

This study found that several [AEDs] showed [inhibitory effects] on [aromatase], including [lamotrigine, oxcarbazepine, tiagabine, phenobarbital, phenytoin, ethosuximide, and valproate]. These findings suggest that [AEDs] could potentially disrupt [hormonal balance] and contribute to [sexual disorders] in individuals receiving these medications. Further research is needed to understand the clinical implications of these findings and develop strategies to mitigate any potential side effects.

Navigating the Hormone Desert

Imagine a delicate balance of hormones within the body, akin to a delicate oasis in a vast desert. This study explores the potential impact of [AEDs] on this delicate balance. The findings highlight the importance of considering the potential for [hormonal disruptions] when prescribing these medications, particularly for women and children. By understanding these potential side effects, healthcare providers can make informed decisions about [treatment plans] and ensure the well-being of their patients.

Dr. Camel's Conclusion

This study sheds light on the complex relationship between AEDs and hormonal balance. The findings underscore the importance of being mindful of potential side effects and ensuring that patients receive the appropriate monitoring and care. Just as a camel adapts to the challenges of a desert environment, so too must we adapt our understanding of medication effects and ensure that patients receive the best possible care.

Date :
  1. Date Completed 2008-03-20
  2. Date Revised 2017-11-16
Further Info :

Pubmed ID

17959350

DOI: Digital Object Identifier

10.1016/j.tiv.2007.09.004

SNS
PICO Info
in preparation
Languages

English

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