Glucocorticoids induce retinal toxicity through mechanisms mainly associated with paraptosis.

Author: Behar-CohenFrancine, BenEzraDavid, GandolpheChristelle, JeannyJean-Claude, SavoldelliMichéle, TorrigliaAlicia, ValamaneshFatemeh

Paper Details 
Original Abstract of the Article :
Corticosteroids have recorded beneficial clinical effects and are widely used in medicine. In ophthalmology, besides their treatment benefits, side effects, including ocular toxicity have been observed especially when intraocular delivery is used. The mechanism of these toxic events remains, however...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/17960113

データ提供:米国国立医学図書館(NLM)

Corticosteroids: A Double-Edged Sword in Ophthalmology

Corticosteroids, powerful anti-inflammatory medications, are widely used in medicine, including ophthalmology. However, their use can come with a risk of ocular toxicity, particularly when delivered directly into the eye. This research explores the mechanisms underlying corticosteroid-induced retinal cell death. The study investigated the pathways involved in corticosteroid-induced retinal toxicity, focusing on the role of paraptosis, a form of programmed cell death. The researchers found that glucocorticoids, a class of corticosteroids, induce retinal toxicity primarily through paraptosis-related mechanisms.

A Deeper Understanding of Retinal Toxicity: Unveiling the Role of Paraptosis

This research provides valuable insights into the mechanisms of corticosteroid-induced retinal toxicity. The study's findings highlight the role of paraptosis, a less well-understood form of cell death, in this process. Understanding the pathways involved in corticosteroid-induced retinal toxicity could lead to the development of strategies to mitigate these risks and improve patient safety.

Navigating the Path to Safer Corticosteroid Use: Minimizing Retinal Toxicity

This research underscores the importance of cautious corticosteroid use in ophthalmology. The study's findings suggest that understanding the mechanisms of retinal toxicity can help healthcare professionals make informed decisions about corticosteroid treatment, minimizing the risk of adverse effects and ensuring optimal patient care.

Dr.Camel's Conclusion

Just as a camel navigates the delicate balance of water conservation in the desert, healthcare professionals carefully navigate the use of corticosteroids in ophthalmology. This research highlights the importance of understanding the mechanisms of retinal toxicity, emphasizing the need for cautious use and informed decision-making to minimize risks and improve the safety of corticosteroid therapy.

Date :
  1. Date Completed 2007-11-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

17960113

DOI: Digital Object Identifier

v13/a195

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English

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