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Independent effects of nevirapine prophylaxis and HIV-1 RNA suppression in breast milk on early perinatal HIV-1 transmission.

Author: ChungMichael H, John-StewartGrace C, KiarieJames N, LehmanDara A, NjiriFrancis, OverbaughJulie, RichardsonBarbra A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Peripartum administration of single-dose nevirapine to mother and infant decreases early perinatal HIV-1 transmission by means of breast milk HIV-1 RNA suppression and, independently, by providing the infant with exposure prophylaxis.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The mechanism of action of single-dose nevirapine on reducing mother-to-child transmission of HIV-1 may involve reduction of maternal HIV-1 or prophylaxis of infants. METHODS: In a study that randomized pregnant mothers to HIVNET 012 nevirapine versus short-course antenatal zidovudine, ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18077838

データ提供：米国国立医学図書館（NLM）

Nevirapine: A Powerful Tool for Preventing Perinatal HIV-1 Transmission

The desert of HIV-1 transmission poses a significant challenge to global health, particularly for mothers and their infants. This study explores the effectiveness of nevirapine, a medication used to prevent mother-to-child transmission of HIV-1. The authors investigated the independent effects of nevirapine prophylaxis and HIV-1 RNA suppression in breast milk on early perinatal HIV-1 transmission.

Nevirapine: A Double-Edged Sword Against HIV-1 Transmission

The study revealed that nevirapine effectively reduces early perinatal HIV-1 transmission by both suppressing HIV-1 RNA levels in breast milk and providing infants with prophylaxis. This finding emphasizes the vital role of nevirapine in preventing vertical transmission of HIV-1, a significant public health concern.

Navigating the Challenges of HIV-1 Transmission

This study highlights the importance of comprehensive interventions to prevent perinatal HIV-1 transmission. The use of nevirapine, alongside other measures like HIV-1 RNA suppression, is crucial in mitigating the risk of mother-to-child transmission, safeguarding the health of both mothers and their infants.

Dr.Camel's Conclusion

This study sheds light on the effectiveness of nevirapine in preventing perinatal HIV-1 transmission. The findings demonstrate that nevirapine plays a crucial role in reducing the risk of mother-to-child transmission, highlighting the importance of comprehensive strategies for combatting this global health challenge.

Date :
  1. Date Completed 2008-01-24
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18077838

DOI: Digital Object Identifier

NIHMS359025

Related Literature

Article Analysis
・Effects of nevirapine
SNS
PICO Info
in preparation
Languages

English

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