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The effect of food and metoclopramide on the pharmacokinetics and side effects of bromocriptine.

Author: FrancetićI, KopitarZ, PlavsićF, PovsicL, UrbancicJ, VrhovacB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Food slightly reduced the peak plasma concentrations of bromocriptine, but did not significantly affect its bioavailability. Metoclopramide pretreatment significantly reduced the side effects of bromocriptine by about 83%.
Paper Details　
Original Abstract of the Article :
The effect of food and metoclopramide on the pharmacokinetics of bromocriptine was investigated in 7 healthy subjects. Plasma concentrations of bromocriptine were measured by radioimmunoassay after a single oral dose of 7.5 mg bromocriptine. Maximal plasma concentrations of bromocriptine were slight...See full text at original site
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引用元：
https://doi.org/10.1007/BF03189956

データ提供：米国国立医学図書館（NLM）

Bromocriptine: Navigating Food and Metoclopramide

Bromocriptine, a medication used to treat various conditions, can be influenced by food and other medications. This study investigates the impact of food and metoclopramide, a drug that accelerates gastric emptying, on the pharmacokinetics and side effects of bromocriptine. Researchers carefully monitored the plasma concentrations of bromocriptine after administering a single dose, evaluating the effects of food and metoclopramide.

Minimizing Side Effects

The study found that food had a minimal impact on bromocriptine's bioavailability, while metoclopramide significantly reduced the incidence of side effects. While food slightly reduced the peak plasma concentration of bromocriptine, it did not significantly affect its overall absorption. Metoclopramide, however, effectively reduced the side effects of bromocriptine by approximately 83%, suggesting that pre-treatment with metoclopramide could enhance patient tolerance and improve treatment outcomes.

Optimizing Bromocriptine Therapy

This research provides valuable insights into the management of bromocriptine therapy. By understanding the influence of food and other medications, healthcare providers can optimize treatment plans to minimize side effects and enhance patient comfort. It's like navigating a desert with a well-stocked caravan, ensuring a smooth and pleasant journey by considering the potential impacts of food and medications.

Dr.Camel's Conclusion

This study, like a seasoned caravan guide, reveals the best strategies for navigating the journey of bromocriptine therapy. By understanding the effects of food and metoclopramide, we can optimize treatment plans, ensuring a more comfortable and effective experience for patients.

Date :
  1. Date Completed 1992-06-23
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

1814735

DOI: Digital Object Identifier

10.1007/BF03189956

Related Literature

Article Analysis
・Side Effects of metoclopramide
SNS
PICO Info
in preparation
Languages

English

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