Antihypertensive therapy with aliskiren.

Author: LuftF C, WeinbergerM H

Paper Details 
Original Abstract of the Article :
Aliskiren represents the first member in a new class of antihypertensive drugs. Inhibiting the renin-angiotensin system at its rate-limiting step is an idea that has been pursued for >30 years; however, earlier compounds failed because of problems related to efficacy, bioavailability, and/or side ef...See full text at original site
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引用元:
https://doi.org/10.1038/sj.ki.5002732

データ提供:米国国立医学図書館(NLM)

Aliskiren: A New Oasis in the Desert of Hypertension

Hypertension, a common health concern, has long been a challenge for physicians seeking effective treatment options. Imagine hypertension as a vast desert, with blood pressure relentlessly rising like a scorching sun. This research introduces aliskiren, a groundbreaking drug that targets the renin-angiotensin system, offering a promising new approach to managing hypertension.

Aliskiren: A Powerful Tool in the Fight Against Hypertension

The research highlights the unique mechanism of action of aliskiren, inhibiting the renin-angiotensin system at its rate-limiting step. It's like finding a hidden spring in the desert, offering a refreshing source of relief. The authors emphasize the drug's favorable pharmacokinetic profile, including its long half-life and lack of metabolism by CYP P450 enzymes. Aliskiren shows promising results in reducing blood pressure, both as monotherapy and in combination with other antihypertensive agents.

Navigating the Landscape of Hypertension Treatment

This research offers a ray of hope for those struggling with hypertension. It's like discovering a new path through the desert, providing a more effective and potentially safer approach to managing this challenging condition. The authors encourage ongoing research to fully understand the long-term implications of aliskiren and explore its potential for preventing cardiovascular and renal complications.

Dr.Camel's Conclusion

This research presents aliskiren as a promising new tool for managing hypertension. Like a resourceful camel navigating a treacherous desert, we must continue to explore new avenues for effective and safe treatment options, ensuring the well-being of those facing this common health challenge.

Date :
  1. Date Completed 2008-03-21
  2. Date Revised 2012-11-15
Further Info :

Pubmed ID

18160962

DOI: Digital Object Identifier

10.1038/sj.ki.5002732

Related Literature

SNS
PICO Info
in preparation
Languages

English

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