Controlled study of heparin versus epoprostenol sodium (prostacyclin) as the sole anticoagulant for chronic hemodialysis.

Author: CaruanaR J, ClyneD, CrowJ W, DiehlJ H, SmithM C, ZinnJ M

Paper Details 
Original Abstract of the Article :
We performed a controlled parallel study comparing the effects of heparin sodium to epoprostenol sodium (prostacyclin sodium, Flolan) during hemodialysis in 30 dialysis patients. Mean fiber bundle volume loss and dialyzer function were similar with both anticoagulation methods. Intradialytic symptom...See full text at original site
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引用元:
https://doi.org/10.1159/000170027

データ提供:米国国立医学図書館(NLM)

Heparin vs. Epoprostenol: A Showdown in the Dialysis Desert

Chronic hemodialysis, a life-sustaining treatment for those with kidney failure, often requires anticoagulation to prevent blood clots. This study investigates the use of two anticoagulants, heparin and epoprostenol, in hemodialysis patients. The researchers conducted a controlled parallel study to compare the effectiveness and safety of these two drugs in 30 dialysis patients. Their findings reveal a fascinating comparison, highlighting the potential advantages and disadvantages of each anticoagulant.

Navigating the Challenges of Dialysis

The study found that both heparin and epoprostenol were effective in preventing blood clots and maintaining dialyzer function during hemodialysis. While both drugs were effective in preventing blood clots, epoprostenol was associated with a higher incidence of intradialytic symptoms. This suggests that epoprostenol, while effective, might not be suitable for all patients. Like navigating a treacherous desert, we need to carefully consider the individual needs of each patient to determine the most appropriate treatment.

Exploring New Frontiers in Dialysis

The study provides valuable insights into the use of epoprostenol as an alternative to heparin in hemodialysis. While epoprostenol can be effective, its potential for causing symptoms might limit its use in some patients. This study is a reminder that there's still room for innovation and exploration in the field of dialysis. We must continue to search for safer and more effective treatment options for patients with kidney failure.

Dr. Camel's Conclusion

This study showcases the potential benefits and challenges of using epoprostenol as an anticoagulant during hemodialysis. The researchers highlight the importance of carefully considering individual patient needs and monitoring for potential side effects. This study emphasizes that the desert of dialysis research is vast and ever-changing, and that we must continuously seek out new and innovative treatment options for patients with kidney failure.
Date :
  1. Date Completed 1992-07-29
  2. Date Revised 2018-02-15
Further Info :

Pubmed ID

1819317

DOI: Digital Object Identifier

10.1159/000170027

Related Literature

SNS
PICO Info
in preparation
Languages

English

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