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Antitumor and biological effects of black pine (pinus nigra) pollen nuclease.

Author: LipovovaP, MatousekJ, OrctovaL, PodzimekT, PouckovaP, SoucekJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Black pine pollen nuclease (PN) demonstrated higher antitumor activity against human melanoma tumors in athymic mice compared to bovine seminal ribonuclease and DNase I. PN was effective at a dose 10 times lower than the other enzymes, but did have some aspermatogenic and embryotoxic side effects.
Paper Details　
Original Abstract of the Article :
The antitumor effect of black pine (Pinus nigra) pollen nuclease (PN) tested in vitro was negligible in comparison with bovine seminal ribonuclease (BS-RNase). However, in the experiments in vivo a significant decrease of the human melanoma tumor size was observed in the mice treated with this nucle...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18237255

データ提供：米国国立医学図書館（NLM）

Black Pine Pollen Nuclease: A Potential Weapon Against Cancer

Cancer is a formidable foe, like a vast and unforgiving desert that can be difficult to conquer. This research explores the antitumor effects of black pine (Pinus nigra) pollen nuclease (PN), a naturally occurring enzyme. The researchers investigated the potential of PN to inhibit the growth of human melanoma tumors in mice.

While PN showed limited antitumor activity in vitro, it significantly reduced tumor size in vivo. Furthermore, PN exhibited lower toxicity and immunogenicity compared to other RNases.

A Potential Weapon in the Fight Against Cancer

This research suggests that PN could be a promising candidate for further investigation as a potential anticancer agent. It's like discovering a hidden oasis in the desert - a potential source of relief from a devastating disease.

A Journey of Discovery

Further research is needed to fully understand the mechanisms of action and potential applications of PN. It's a journey of discovery through the desert of cancer research, seeking new and effective treatments.

Dr.Camel's Conclusion

This research provides a fascinating glimpse into the potential of natural compounds for fighting cancer. While more research is needed to translate these findings into clinical applications, the initial results are encouraging, suggesting that PN could be a valuable tool in the fight against this devastating disease.

Date :
  1. Date Completed 2008-08-05
  2. Date Revised 2009-11-03
Further Info :

Pubmed ID

18237255

DOI: Digital Object Identifier

18237255

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Languages

English

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