Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir.

Author: DonovanBrian J, HollowellStephanie B, KashubaAngela D M, MinSherene S, RaaschRalph H, RezkNaser L, RubleinJohn C, SmithPhilip C, TallmanMelanie N, TappouniHiba L, TheodoreDickens, TienHsiao-Chuan

Paper Details 
Original Abstract of the Article :
PURPOSE: The effects of omeprazole on indinavir when administered alone or in combination with ritonavir were evaluated. METHODS: Fourteen men and women age 18-55 years not infected with human immunodeficiency virus who met study qualifications were randomized to receive placebo, 20 mg of omeprazol...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/18281734

データ提供:米国国立医学図書館(NLM)

A Study on the Impact of Omeprazole on Indinavir Levels

The world of drug interactions is like a vast desert, full of hidden complexities and potential pitfalls. This study investigates the effects of omeprazole, a drug commonly used to treat heartburn and acid reflux, on indinavir, an antiviral medication used to treat HIV infection. The study explores the impact of omeprazole on the levels of indinavir in the blood. The researchers found that omeprazole significantly reduced the levels of indinavir in the blood, which could potentially impair its effectiveness. However, the study also revealed that the addition of ritonavir, another drug used to enhance the effectiveness of indinavir, could counteract the negative effects of omeprazole. This study is like a guide through a desert, helping us navigate the complex landscape of drug interactions.

Omeprazole Can Reduce Indinavir Levels

This study's findings are important for clinicians and patients alike. The researchers discovered that omeprazole can significantly reduce the levels of indinavir in the blood. This reduction could potentially compromise the effectiveness of indinavir in treating HIV infection. It's like a mirage in the desert, an illusion that could lead to unexpected consequences if not addressed.

Understanding the Interaction

It's crucial to understand the potential interactions between medications, especially when it comes to medications that are critical for maintaining health. This study provides valuable insights into the interplay between omeprazole and indinavir, highlighting the importance of careful monitoring and consideration of potential interactions when these drugs are used together. It's like a well in the desert, providing vital information to help us navigate the complexities of medication use.

Dr.Camel's Conclusion

This study underscores the delicate balance that exists in the world of drug interactions. Understanding these interactions, like navigating through a desert of potential complications, is crucial for ensuring optimal patient care. The study's findings serve as a reminder to be vigilant about potential drug interactions, ensuring that medications work effectively without causing unforeseen consequences.

Date :
  1. Date Completed 2008-03-06
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18281734

DOI: Digital Object Identifier

NIHMS101381

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Languages

English

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