Differential regional and dose-related effects of asenapine on dopamine receptor subtypes.

Author: HenryBrian, Moran-GatesTaylor, ShahidMohammed, TaraziFrank I, WongErik H F

Paper Details 
Original Abstract of the Article :
RATIONALE: The novel psychopharmacologic agent, asenapine, has high affinity for a range of receptors including the dopaminergic receptors. OBJECTIVE: We examined the long-term effects of multiple doses of asenapine on dopamine receptor subtypes: D(1)-like (D(1) and D(5)), D(2), D(3), and D(4). ME...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1007/s00213-008-1098-7

データ提供:米国国立医学図書館(NLM)

Asenapine: A Novel Psychopharmacological Agent with Region-Specific Effects on Dopamine Receptors

This research delves into the intricate workings of the brain, exploring the effects of asenapine, a novel psychopharmacological agent, on dopamine receptors. It's like venturing into the hidden chambers of the brain, a vast and complex desert of neural pathways and neurotransmitters. The study examines the long-term effects of different doses of asenapine on various dopamine receptor subtypes, revealing intriguing region-specific patterns.

Asenapine: A Unique Influence on Dopamine Receptor Subtypes

The study reveals that asenapine has a distinct influence on dopamine receptor subtypes, depending on the specific brain region. It's like discovering a hidden oasis with different varieties of water sources, each nourishing specific parts of the desert. The findings suggest that asenapine's unique psychopharmacological properties may be linked to its distinct impact on dopamine receptors in different brain areas.

Understanding the Brain: Unveiling the Mechanisms of Psychopharmacological Agents

This research provides valuable insights into the complex interplay between psychopharmacological agents and dopamine receptors in the brain. It's like gaining a new perspective on the intricate desert landscape of neurotransmission, revealing the hidden pathways that govern our thoughts and behaviors. By understanding these mechanisms, we can develop more targeted and effective treatments for mental health conditions.

Dr.Camel's Conclusion

This study uncovers the fascinating and intricate relationship between asenapine and dopamine receptors in the brain. It's like venturing deep into a hidden cave system, revealing a labyrinth of pathways and connections. Understanding these nuances can lead to a deeper comprehension of the brain's workings and offer new avenues for developing therapeutic interventions.
Date :
  1. Date Completed 2008-11-17
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

18297468

DOI: Digital Object Identifier

10.1007/s00213-008-1098-7

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.