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Effect of coadministered ketoconazole, a strong cytochrome P450 3A4 enzyme inhibitor, on the pharmacokinetics of ciclesonide and its active metabolite desisobutyryl-ciclesonide.

Author: BöhmerGabriele M, DrollmannAnton, GleiterChristoph H, NaveRüdiger

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ketoconazole inhibits the metabolism of desisobutyryl-ciclesonide, the active metabolite of ciclesonide, indicating a potential drug interaction.
Paper Details　
Original Abstract of the Article :
Cytochrome P450 (CYP) 3A4 isoenzyme has been identified in vitro as the key enzyme to metabolize desisobutyryl-ciclesonide (des-CIC), the pharmacologically active metabolite of the inhaled corticosteroid ciclesonide. This pharmacokinetic drug-drug interaction study was conducted to confirm this majo...See full text at original site
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引用元：
https://doi.org/10.2165/00003088-200847050-00005

データ提供：米国国立医学図書館（NLM）

Effect of Coadministered Ketoconazole, a Strong Cytochrome P450 3A4 Enzyme Inhibitor, on the Pharmacokinetics of Ciclesonide and Its Active Metabolite Desisobutyryl-ciclesonide

This study explores the potential drug interaction between [ciclesonide], an [inhaled corticosteroid], and [ketoconazole], a strong [cytochrome P450 3A4 enzyme inhibitor]. The researchers investigated the effects of [ketoconazole] on the pharmacokinetics of [ciclesonide] and its active metabolite [desisobutyryl-ciclesonide]. Their findings are crucial for understanding the potential drug interactions and ensuring the safe and effective use of these medications.

Ketoconazole and Ciclesonide: A Potential Interaction

The study's results demonstrate that [ketoconazole] significantly impacted the pharmacokinetics of [ciclesonide] and its active metabolite. This finding highlights the importance of considering the potential drug interactions between [ciclesonide] and [ketoconazole] and the need for careful monitoring when these medications are used concurrently.

Navigating Drug Interactions: A Crucial Step in Patient Care

This research underscores the critical role of considering potential drug interactions in patient care. Understanding the pharmacokinetic and pharmacodynamic interactions between medications is essential for ensuring the safe and effective use of medications, particularly when prescribing medications that may interact with each other.

Dr. Camel's Conclusion

Navigating the complex world of drug interactions can feel like traversing a desert of potential side effects. This research serves as a reminder of the importance of understanding drug interactions and the need for careful medication management to ensure patient safety and optimal treatment outcomes.

Date :
  1. Date Completed 2008-09-25
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18399715

DOI: Digital Object Identifier

10.2165/00003088-200847050-00005

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・Effects of ciclesonide oral inhalation
SNS
PICO Info
in preparation
Languages

English

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