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Effects of three years of low-dose thiazides on mineral metabolism in healthy elderly persons.

Author: IchikawaL E, LaCroixA Z, OttS M, ScholesD, WuK

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Hydrochlorothiazide can reduce urine calcium and increase serum bicarbonate, potentially benefiting the skeleton.
Paper Details　
Original Abstract of the Article :
In this clinical trial of 12.5 or 25 mg/day of hydrochlorothiazide, the urine calcium showed significant decreases from placebo in men at one year, but the effects had waned by 3 years. Serum bicarbonate was consistently greater in the thiazide than in the placebo groups throughout the three years. ...See full text at original site
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引用元：
https://doi.org/10.1007/s00198-008-0612-4

データ提供：米国国立医学図書館（NLM）

Thiazides and Bone Health: A Camel's Take

This study is like a compass navigating the complex landscape of bone health. Researchers investigated the effects of low-dose thiazides, a type of diuretic, on mineral metabolism in healthy elderly individuals. The study was conducted over three years, providing a detailed examination of the long-term effects of these medications.

Thiazides and Bone Health: A Balancing Act

The study found that thiazides had a mixed impact on bone health. While they led to a temporary decrease in urine calcium in men, this effect faded over time. However, thiazides consistently increased serum bicarbonate levels, potentially beneficial for bone health. It's a balancing act, with potential benefits and considerations to keep in mind.

A Camel's Perspective on Bone Health

Think of your bones as the sturdy backbone of a camel, carrying you through the toughest journeys. Maintaining bone health, particularly as we age, is crucial. This study offers valuable insights into the potential effects of thiazides on bone metabolism. It's essential to discuss your medications and any potential risks and benefits with your doctor, especially if you are taking thiazides.

Dr. Camel's Conclusion

This research is like a fascinating journey across a desert landscape, revealing the intricate relationship between medications and bone health. While thiazides seem to have a complex impact on bone metabolism, the study highlights the importance of careful monitoring and personalized medical advice in navigating the delicate balance of our health.

Date :
  1. Date Completed 2009-05-06
  2. Date Revised 2022-07-16
Further Info :

Pubmed ID

18425402

DOI: Digital Object Identifier

10.1007/s00198-008-0612-4

Related Literature

Article Analysis
・Effects of hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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