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Blockade of M1 muscarinic acetylcholine receptors modulates the methamphetamine-induced psychomotor stimulant effect.

Author: HaR-R, JangC-G, KimH-C, KwonS-H, LeeK-W, LeeS-Y, TianY-H, YouI-J

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Methamphetamine (METH) can increase the expression of M1 muscarinic receptors in the brain, which may contribute to its stimulant effects. Blocking these receptors with dicyclomine can alter METH's effects on dopamine release.
Paper Details　
Original Abstract of the Article :
Muscarinic acetylcholine receptors (M1-M5) regulate many key functions of the CNS and peripheral nervous system. In the present study, the role of M1 muscarinic receptors (M1R) in the psychomotor stimulant and sensitizing properties of methamphetamine (METH) is investigated using molecular, neuroche...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuroscience.2008.02.021

データ提供：米国国立医学図書館（NLM）

The Role of M1 Muscarinic Receptors in Methamphetamine's Effects

This research delves into the intricate workings of the brain, exploring the role of M1 muscarinic receptors (M1R) in the psychomotor stimulant effects of methamphetamine (METH). The study, like a camel traversing the desert, examines the effects of METH on M1R expression in various brain regions. The researchers discovered that METH increased M1R expression in the frontal cortex and hippocampus, while also influencing dopamine (DA) release in the nucleus accumbens (NAc). This finding suggests that M1R plays a crucial role in mediating METH's psychomotor stimulant effects.

A Complex Dance Between M1 Receptors and Methamphetamine

This research unveils a complex interplay between M1R and METH, demonstrating that M1R plays a critical role in mediating the psychomotor stimulant effects of METH. The study's findings are a valuable addition to our understanding of the brain's intricate response to this potent drug.

Navigating the Desert of Methamphetamine Addiction

This research highlights the complex role of M1R in the brain's response to METH. Understanding this intricate relationship is crucial for developing more effective treatments for methamphetamine addiction and reducing its detrimental effects on individuals and society. This discovery is like finding a hidden oasis in the desert of addiction, offering hope for new therapeutic approaches.

Dr.Camel's Conclusion

This research provides valuable insights into the intricate interplay between M1R and METH, unraveling a complex mechanism in the brain's response to this potent stimulant. This understanding could pave the way for new therapeutic approaches to combat methamphetamine addiction, making a tangible impact on the lives of individuals struggling with this challenging condition.

Date :
  1. Date Completed 2008-10-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18455881

DOI: Digital Object Identifier

10.1016/j.neuroscience.2008.02.021

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Article Analysis
・Effects of dicyclomine
SNS
PICO Info
in preparation
Languages

English

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