Topotecan treatment and its toxic effects on hematologic parameters and trace elements.

Author: AlbayrakMeryem, ApanAlpaslan, Bayar MulukNuray, Bülbül HizelSelda, OzyaziciAhmet, SanliCihat

Paper Details 
Original Abstract of the Article :
The aim of this study was to investigate the effects of topotecan, a topoisomerase I-inhibiting anticancer agent, on hematologic parameters and serum levels of trace elements. The study was conducted on three groups consisting of 16 and 18 rabbits in the study groups and 15 rabbits in the control gr...See full text at original site
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引用元:
https://doi.org/10.1007/s12011-008-8140-9

データ提供:米国国立医学図書館(NLM)

Topotecan: A Double-Edged Sword in Cancer Treatment

The world of cancer treatment is often a delicate balancing act, much like walking through a shifting desert landscape. This research explores the effects of [topotecan], a powerful [anticancer agent], on [hematologic parameters and trace elements]. The study involved [three groups of rabbits] to assess the impact of different [dosages] of topotecan.

The Cost of Killing Cancer Cells

The researchers found that [topotecan treatment] significantly decreased [erythrocyte counts and hemoglobin levels], suggesting potential [bone marrow suppression]. However, [thrombocyte and leukocyte counts] remained relatively stable. Furthermore, [selenium levels] were notably lower in the treated groups, prompting the consideration of [selenium supplementation] in cancer patients undergoing topotecan therapy.

Navigating the Side Effects of Cancer Treatment

This research serves as a reminder that [anticancer treatments], while vital in combating cancer, can sometimes come with [unforeseen side effects]. Understanding the impact of these drugs on [hematologic parameters and trace elements] allows for [better informed treatment strategies]. The potential benefits of [selenium supplementation] warrant further investigation as a means of [mitigating the negative effects] of topotecan therapy.

Dr.Camel's Conclusion

Just as a desert can be both beautiful and harsh, the world of cancer treatment is a delicate balance between hope and challenge. This research sheds light on the potential side effects of topotecan, emphasizing the importance of careful monitoring and consideration of supplemental therapies to optimize patient outcomes.

Date :
  1. Date Completed 2008-11-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18498005

DOI: Digital Object Identifier

10.1007/s12011-008-8140-9

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English

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