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Antagonism of muscarinic M1 receptors by dicyclomine inhibits the consolidation of morphine-associated contextual memory.

Author: BassedaZahra, DehpourAhmad Reza, EsmaeiliBehnaz

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

M1 muscarinic receptors are involved in memory and learning. This study found that blocking M1 receptors in mice reduced their preference for a place associated with morphine. This suggests that M1 receptors play a role in the consolidation of memories related to reward.
Paper Details　
Original Abstract of the Article :
M1 muscarinic receptor has been shown to be involved in cognitive functions of the brain. Conditioned place preference (CPP) paradigm involves memory for the association between environmental stimuli and the rewarding properties produced by a treatment. Using a balanced CPP design, we studied the po...See full text at original site
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引用元：
https://doi.org/10.1016/j.brainresbull.2008.02.003

データ提供：米国国立医学図書館（NLM）

Unraveling the Role of Muscarinic M1 Receptors in Morphine-Associated Memory

The intricate workings of the brain and its role in memory formation continue to fascinate researchers. This [study] delves into the potential involvement of muscarinic M1 receptors in the consolidation of morphine-associated contextual memory. Using a conditioned place preference (CPP) paradigm, the authors investigate the specific role of M1 receptors in different phases of memory formation.

M1 Receptors: A Key Player in the Consolidation of Morphine-Associated Memory

The study's findings suggest that M1 muscarinic receptors play a crucial role in the [consolidation phase of morphine-associated contextual memory]. Blocking M1 receptors during this phase significantly reduced the time spent by mice in the morphine compartment, indicating that M1 receptors are essential for the stabilization and strengthening of these reward-related memories.

Implications for Understanding Memory and Addiction

This research contributes to our understanding of the [neural mechanisms] underlying memory formation and addiction. The involvement of M1 receptors in the consolidation of morphine-associated memories could have implications for developing novel therapeutic strategies for treating drug addiction, potentially targeting these receptors to prevent the formation of drug-related cravings and relapse.

Dr. Camel's Conclusion

This study is like a journey deep into the desert of the brain, revealing the hidden pathways involved in the formation of memories associated with rewarding experiences. The findings suggest that targeting M1 receptors might be a promising approach to combating drug addiction. This research is a reminder of the complexity of the brain and the fascinating ways in which it shapes our experiences and behaviors.
Date :
  1. Date Completed 2008-07-16
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

18502314

DOI: Digital Object Identifier

10.1016/j.brainresbull.2008.02.003

Related Literature

Article Analysis
・Effects of dicyclomine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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