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[Possibilities of antioxidant therapy in the prevention of side effects of amiodarone].

Author: FehérE, FehérJ, FóldiákG, GyörgyI, ToncsevH, TóthM, VereckeiA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Amiodarone, an antiarrhythmic drug, generated a very reactive phenyl radical, which contributed to lysosomal phospholipoidosis. Silibinin, a flavonoid antioxidant, significantly decreased lysosomal phospholipoidosis but did not completely prevent its accumulation.
Paper Details　
Original Abstract of the Article :
The authors demonstrated the generation of a very reactive phenyl radical from amiodarone in a reducing molecular environment by pulse radiolysis study. The various antioxidants are probably not capable of preventing the generation of phenyl radical, as well as to protect against its damaging effect...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1852439

データ提供：米国国立医学図書館（NLM）

Antioxidant Therapy: A Potential Shield Against Amiodarone's Side Effects

Amiodarone is a widely used antiarrhythmic medication, but it can cause significant side effects, including pulmonary toxicity. This research explores the potential of antioxidants in mitigating the adverse effects of amiodarone. The study investigates the role of free radical reactions in amiodarone-induced lysosomal phospholipoidosis, a condition that can lead to lung damage.

Antioxidants in Action: A Balancing Act

The study found that while antioxidants may not entirely prevent the generation of reactive free radicals from amiodarone, they can potentially reduce the extent of lysosomal phospholipoidosis. Specifically, Silibinin, a flavonoid antioxidant, was shown to significantly decrease lysosomal phospholipoidosis in treated rats.

Minimizing Amiodarone-Related Toxicity: Exploring Protective Strategies

This research suggests that antioxidants could potentially play a role in mitigating the side effects of amiodarone. Further research is warranted to explore the optimal use of antioxidants in conjunction with amiodarone therapy to minimize the risk of pulmonary toxicity.

Dr. Camel's Conclusion

Amiodarone, like a scorching desert sun, can have both beneficial and harmful effects. This research sheds light on the potential of antioxidants as a protective shield against amiodarone's side effects, offering hope for safer and more effective treatment strategies.

Date :
  1. Date Completed 1991-08-21
  2. Date Revised 2016-11-23
Further Info :

Pubmed ID

1852439

DOI: Digital Object Identifier

1852439

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・Side Effects of amiodarone
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in preparation
Languages

Hungarian

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