Neuroophthalmological side effects following intrathecal administration of liposomal cytarabine for central nervous system prophylaxis in three adolescents with acute myeloid leukaemia.

Author: BeneschMartin, BergloeffJutta, GruberAnna, LacknerHerwig, MoserAndrea, SchwingerWolfgang, SommerConstanze, SovinzPetra, UrbanChristian

Paper Details 
Original Abstract of the Article :
Three adolescents with central nervous system (CNS) negative acute myeloid leukaemia (AML) refused cranial irradiation for CNS prophylaxis. Instead, these patients received four doses of 50 mg of intrathecal (IT) liposomal cytarabine on day 1, 15, 43 and 71 of maintenance therapy. Corticosteroids we...See full text at original site
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引用元:
https://doi.org/10.1007/s00277-008-0521-9

データ提供:米国国立医学図書館(NLM)

Neuroophthalmological Side Effects of Liposomal Cytarabine for CNS Prophylaxis

The battle against acute myeloid leukemia (AML) is like a challenging desert expedition. This case report explores the neuroophthalmological side effects of liposomal cytarabine, a drug used to prevent AML from spreading to the central nervous system (CNS). The case highlights the potential risks and challenges associated with this treatment approach, underscoring the importance of careful monitoring and management.

Navigating the Side Effects of Treatment

The report describes three adolescents with AML who developed bilateral papilledema, a swelling of the optic nerve, after receiving liposomal cytarabine. This is like encountering a sudden sandstorm during a desert journey, obscuring vision and making it difficult to navigate. The study emphasizes the need to be aware of potential side effects and to develop strategies for managing them effectively.

A Careful Approach to CNS Prophylaxis

This case report serves as a reminder that even in the face of serious illnesses like AML, it is essential to carefully consider all treatment options and potential risks. This is like choosing a safe and well-maintained route through the desert, minimizing the risk of encountering unforeseen hazards. Understanding the potential side effects of medications can help physicians and patients make informed decisions and navigate the treatment journey with greater confidence.

Dr. Camel's Conclusion

This case report underscores the importance of recognizing the potential side effects of liposomal cytarabine in CNS prophylaxis. The neuroophthalmological side effects experienced by these adolescents illustrate the need for vigilance and careful management of treatment, ensuring a safe and effective journey through the desert of AML.

Date :
  1. Date Completed 2008-11-12
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18575860

DOI: Digital Object Identifier

10.1007/s00277-008-0521-9

SNS
PICO Info
in preparation
Languages

English

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