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Interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning.

Author: FerreiraTatiana Lima, FigueredoLarissa Zeggio Perez, FornariRaquel Vecchio, MoreiraKarin Monteiro, OliveiraMaria Gabriela Menezes

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the role of M1-muscarinic receptors in mediating the interaction between the glutamatergic and cholinergic systems in learning and memory processes. Concomitant administration of sub-effective doses of MK-801 (NMDA antagonist) and dicyclomine (M1-muscarinic antagonist) impaired contextual fear conditioning (hippocampal-dependent task) but not tone fear conditioning (hippocampal-independent task). This supports the hypothesis that the interaction between the glutamatergic and cholinergic systems in hippocampus-dependent learning and memory processes occurs through M1 receptors.
Paper Details　
Original Abstract of the Article :
A number of studies have suggested that the glutamatergic and cholinergic systems are both involved in learning and memory processes and that they interact in order to facilitate these processes. However, the role of M1-muscarinic receptors in mediating this interaction has not been elucidated. The ...See full text at original site
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引用元：
https://doi.org/10.1016/j.brainresbull.2008.05.008

データ提供：米国国立医学図書館（NLM）

Fear Conditioning: Navigating the Maze of Memory

Fear conditioning is a complex process, involving the intricate interplay of neural pathways. It's like exploring a vast labyrinth of memory, where each turn and twist represents a different aspect of fear learning. This study investigates the interaction between glutamatergic-NMDA and cholinergic-muscarinic systems in classical fear conditioning, seeking to understand the role of M1-muscarinic receptors in this intricate dance. It's like uncovering the secrets of a hidden map, revealing the pathways that connect different areas of the memory maze.

M1 Receptors: A Key Player in Fear Conditioning

The study found that the combination of MK-801 (NMDA antagonist) and dicyclomine (M1-muscarinic antagonist) impaired contextual fear conditioning but not tone fear conditioning. It's like discovering that a specific pathway through the memory maze is crucial for one type of fear learning but not another. These findings suggest that M1 receptors play a significant role in hippocampus-dependent learning and memory processes, like a critical checkpoint in the labyrinth of fear.

Unraveling the Mystery of Fear

Understanding the interplay between these neurotransmitter systems is crucial for developing effective treatments for anxiety disorders. It's like acquiring the knowledge needed to navigate the maze of fear, potentially leading to a path towards greater well-being. Further research is needed to fully understand the role of M1 receptors and to develop targeted interventions that can help individuals overcome fear and anxiety.

Dr. Camel's Conclusion

This study sheds light on the intricate mechanisms of fear conditioning, uncovering the critical role of M1 receptors in this process. It's like adding a piece to the puzzle of fear, helping us to understand the complex landscape of memory and learning. This research offers a valuable starting point for developing new strategies to address fear and anxiety disorders.

Date :
  1. Date Completed 2008-10-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

18582541

DOI: Digital Object Identifier

10.1016/j.brainresbull.2008.05.008

Related Literature

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・Effects of dicyclomine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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