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[Metabolic side effects of antiretroviral therapy].

Author: ReissP, van der ValkM

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Antiretroviral therapy for HIV-I-infections can cause several metabolic side effects, including adipose redistribution syndrome, lactate acidosis, hyperlactaemia, and insulin resistance. Some protease inhibitors (PIs) and nucleoside-reverse-transcriptase inhibitors (NRTIs) contribute to these issues. While PIs and some NRTIs increase the risk of cardiovascular disease, the metabolic side effects are outweighed by the beneficial effects of the antiretroviral agents. Counteracting these side effects should not compromise antiretroviral therapy. Pravastatin is recommended as cholesterol-lowering therapy due to its low interaction risk with PIs.
Paper Details　
Original Abstract of the Article :
Antiretroviral therapy for HIV-I-infections is accompanied with the occurrence of several metabolic side effects. An often encountered complication of antiretroviral therapy is the adipose redistribution syndrome characterised by an altered distribution of body fat, and linked with protease inhibito...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/18590059

データ提供：米国国立医学図書館（NLM）

Navigating the Metabolic Side Effects of Antiretroviral Therapy: A Balancing Act

In the ever-evolving landscape of HIV treatment, we find ourselves at a crossroads, seeking to understand the impact of antiretroviral therapy on metabolic health. This study delves into the complex relationship between antiretroviral therapy and metabolic side effects, exploring a range of concerns from adipose redistribution syndrome to insulin resistance. Like a desert oasis, this research offers valuable insights into the complexities of this crucial treatment modality.

Metabolic Side Effects: A Complex Landscape

The authors meticulously examine the diverse metabolic side effects associated with antiretroviral therapy, highlighting the impact of protease inhibitors (PIs) and nucleoside-reverse-transcriptase inhibitors (NRTIs) on fat distribution, lactate levels, and insulin resistance. They even delve into the intricate interactions between PIs and statins, emphasizing the importance of personalized treatment approaches. This comprehensive exploration provides a clear picture of the potential metabolic challenges faced by patients undergoing antiretroviral therapy.

Balancing Benefits and Risks: A Delicate Dance

Despite these potential metabolic side effects, the authors emphasize the undeniable benefits of antiretroviral therapy in combatting HIV infection. They advocate for a balanced approach, aiming to manage these side effects without compromising the effectiveness of the therapy. This calls for a collaborative approach between patients and healthcare providers to navigate the intricate terrain of antiretroviral treatment.

Dr.Camel's Conclusion

This research, like a shimmering mirage in the desert, reveals the complex relationship between antiretroviral therapy and metabolic health. While antiretroviral therapy offers life-saving benefits, understanding and managing its metabolic side effects is crucial for ensuring patient well-being. This study underscores the importance of ongoing research and collaboration in this field to find solutions that optimize treatment outcomes for patients living with HIV.

Date :
  1. Date Completed 2008-07-29
  2. Date Revised 2008-07-01
Further Info :

Pubmed ID

18590059

DOI: Digital Object Identifier

18590059

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