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Cabergoline and pramipexole fail to modify already established dyskinesias in an animal model of parkinsonism.

Author: FerrarioJuan E, GershanikOscar S, LarramendyCelia, MurerMario G, SaboridoMariano D, TaraviniIrene R E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

D2 dopamine agonists are less prone to induce levodopa-induced dyskinesias than levodopa itself. This study found that pramipexole, a D2 agonist with a shorter half-life, was more likely to induce dyskinesias in rats pre-treated with levodopa. However, de novo treatment with D2 agonists was associated with a lower risk of dyskinesias.
Paper Details　
Original Abstract of the Article :
Levodopa-induced dyskinesias are one of the major limiting side effects encountered in the treatment of Parkinson's disease. Dopamine agonists of the D2 family are less prone to induce these abnormal involuntary movements (AIMs), and in some instances it has been proposed that they could counteract ...See full text at original site
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引用元：
https://doi.org/10.1016/j.bbr.2008.06.021

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 2009-01-15
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18638507

DOI: Digital Object Identifier

10.1016/j.bbr.2008.06.021

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Languages

English

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