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Differential effects of ziprasidone and haloperidol on immobilization stress-induced mRNA BDNF expression in the hippocampus and neocortex of rats.

Author: ChoiSang Mi, KimNa Ri, KimYoung Hoon, LeeChan Hong, LeeJung Goo, LeeSun Jung, ParkSung Woo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Ziprasidone may have neuroprotective effects by attenuating stress-induced decreases in brain-derived neurotrophic factor (BDNF) mRNA expression in the rat hippocampus and neocortex.
Paper Details　
Original Abstract of the Article :
Recent in vivo and in vitro experiments have demonstrated that second-generation antipsychotic drugs (SGAs) might have neuroprotective effects. Ziprasidone is a SGA that is efficacious in the treatment of schizophrenia. In this study, we sought to analyze the effects of ziprasidone on the expression...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpsychires.2008.05.010

データ提供：米国国立医学図書館（NLM）

Ziprasidone's Neuroprotective Potential: A Glimpse into its Effects on BDNF Expression

The field of neuroscience is constantly exploring the intricate mechanisms of the brain and seeking new avenues for treating mental health conditions. This study investigates the effects of ziprasidone, a second-generation antipsychotic drug, on the expression of brain-derived neurotrophic factor (BDNF), a protein crucial for brain health and neuroprotection.

Ziprasidone's Protective Effects on BDNF Expression

This research found that ziprasidone exhibited neuroprotective effects by attenuating the stress-induced decrease in BDNF mRNA expression in the rat hippocampus and neocortex. This finding suggests that ziprasidone might have a protective role in the brain, potentially contributing to its therapeutic efficacy in treating schizophrenia.

A New Avenue for Neuroprotection

This research sheds light on the potential neuroprotective effects of ziprasidone, opening a new avenue for exploring its therapeutic benefits beyond its antipsychotic properties. It's a glimpse into the desert of neurobiology, uncovering new pathways to understand and treat complex mental health conditions.

Dr.Camel's Conclusion

This study provides a fascinating look into the neuroprotective potential of ziprasidone. By investigating its effects on BDNF expression, the research offers valuable insights into its mechanisms of action and potential therapeutic benefits. It's a journey into the depths of the brain, seeking new ways to enhance brain health and well-being.

Date :
  1. Date Completed 2009-03-19
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

18656896

DOI: Digital Object Identifier

10.1016/j.jpsychires.2008.05.010

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Languages

English

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