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A ketolide antibiotic, telithromycin, inhibits vascular adrenergic neurotransmission in the rat mesenteric vascular bed.

Author: HatanakaY, HobaraN, JinX, KawasakiH, KitamuraY, KoyamaT, ZamamiY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the effects of telithromycin, a ketolide antibiotic, on perivascular nerve function in rat mesenteric arteries. Telithromycin was found to have negative effects on nerve function, while macrolides and new quinolone antibiotics had less of an impact.
Paper Details　
Original Abstract of the Article :
A ketolide antibiotic, telithromycin, has side effects including temporary loss of consciousness in clinical use, but the underlying mechanisms remain unclear. This study investigated the effects of telithromycin on perivascular nerve function in rat mesenteric arteries, in comparison with those of ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597235/

データ提供：米国国立医学図書館（NLM）

Telithromycin: A Ketolide Antibiotic with Potential Cardiovascular Effects

Telithromycin, a ketolide antibiotic, has been reported to cause side effects such as temporary loss of consciousness. This research investigates the effects of telithromycin on vascular adrenergic neurotransmission in the rat mesenteric vascular bed. The study compares the effects of telithromycin to other antibiotics, including macrolides and quinolones. The findings suggest that telithromycin inhibits vascular adrenergic neurotransmission, potentially explaining its cardiovascular side effects.

Exploring the Cardiovascular Effects of Telithromycin

This research provides valuable insights into the potential cardiovascular effects of telithromycin. The study reveals that telithromycin can inhibit vascular adrenergic neurotransmission, potentially contributing to its reported side effects. These findings underscore the importance of understanding the potential cardiovascular risks associated with antibiotic use.

Antibiotics and Cardiovascular Health: A Balancing Act

Antibiotics are essential for treating bacterial infections. This research highlights the need for caution when using certain antibiotics, such as telithromycin, due to their potential cardiovascular effects. It emphasizes the importance of weighing the risks and benefits of antibiotic treatment and considering alternative therapies when appropriate.

Dr.Camel's Conclusion

Just as a camel's heart beats steadily through the desert heat, our own hearts are delicate organs that require careful attention. This research reminds us that even medications intended to treat one ailment can have unintended effects on other systems, highlighting the importance of understanding the full spectrum of potential risks and benefits associated with medical treatments.

Date :
  1. Date Completed 2009-02-20
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

18695647

DOI: Digital Object Identifier

PMC2597235

Related Literature

Article Analysis
・Side Effects of telithromycin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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