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Opposite effects of metoclopramide and propantheline on intestinal absorption of imipramine in rats.

Author: ImamuraY, OtagiriM, UchiyamaS

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Metoclopramide markedly increased the serum concentration of imipramine by counteracting the gastric emptying delay caused by imipramine, while propantheline slightly decreased the serum concentration by strengthening the gastric emptying delay.
Paper Details　
Original Abstract of the Article :
Intraperitoneally administered metoclopramide (MCP) markedly increased the serum concentration of imipramine (IPM) soon after oral administration. In contrast, intraperitoneally administered propantheline (PPT) slightly decreased the serum concentration. The administration of these two drugs had no ...See full text at original site
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引用元：
https://doi.org/10.1248/bpb1978.14.66

データ提供：米国国立医学図書館（NLM）

Navigating the Intestines: A Tale of Two Drugs

This research explores the impact of two drugs, metoclopramide (MCP) and propantheline (PPT), on the absorption of imipramine (IPM) in the intestines. It's like studying the flow of a river—how different currents affect the journey of a boat. The study found that MCP significantly increased the absorption of IPM, while PPT slightly decreased it. This discovery can help us understand how different drugs interact within our bodies.

Metoclopramide: A Guiding Force in the Intestine

The study revealed that MCP acts as a guiding force in the intestine, helping IPM to be absorbed more effectively. This is like a strong current that carries a boat swiftly downstream—it accelerates the journey of IPM.

Propantheline: A Gentle Slowdown in the Intestine

In contrast, PPT slows down the journey of IPM in the intestine. This is like a gentle breeze that slows down a sailboat—it delays the absorption of IPM.

Dr.Camel's Conclusion

This study reveals the complex interplay of different drugs within our bodies. By understanding how these drugs interact, we can optimize their use and achieve better outcomes.

Date :
  1. Date Completed 1991-09-19
  2. Date Revised 2019-09-12
Further Info :

Pubmed ID

1870075

DOI: Digital Object Identifier

10.1248/bpb1978.14.66

Related Literature

Article Analysis
・Effects of propantheline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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