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Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study.

Author: BoernerR, DreselS, FrodlT, GründerG, HahnK, MeisenzahlE M, MöllerH-J, ScheuereckerJ, SchmittG, SchwarzM, StaussJ, la FougèreC

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Amisulpride is an effective atypical antipsychotic drug that can block dopamine D2 receptors. In a study of 29 patients with schizophrenia or schizoaffective disorder, amisulpride significantly decreased D2 receptor binding in the brain. While 31% of the patients experienced extrapyramidal side effects, the drug showed good tolerability and efficacy.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: Amisulpride appears to be an effective atypical agent for treating schizophrenia in a dose-dependent manner. METHODS: 29 patients suffering from schizophrenia or schizoaffective disorder were treated with a broad dose range of amisulpride (50-1 200 mg/day, mean: 455.2+/-278.8 mg/day)....See full text at original site
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引用元：
https://doi.org/10.1055/s-2008-1076727

データ提供：米国国立医学図書館（NLM）

Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study

The [neurological] desert is a vast and complex landscape, filled with intricate pathways and delicate balances. This study delves into the [pharmacological effects] of amisulpride, an atypical antipsychotic medication used to treat [schizophrenia], by examining its impact on dopamine receptor occupancy in the brain.

Dopamine Receptor Occupancy and Clinical Response

The researchers used [single photon emission computed tomography (SPECT)] to measure the occupancy of [dopamine D2 receptors] in the striatum of patients treated with amisulpride. The study found that amisulpride produced significant [striatal D2 receptor blockade] in a dose-dependent manner, highlighting its ability to target specific brain regions involved in schizophrenia.

Clinical Implications

The study's findings suggest that amisulpride, while demonstrating [good efficacy] in treating schizophrenia, also carries a [risk of extrapyramidal side effects]. This underscores the need for careful monitoring and management of side effects in patients treated with this medication.

Dr. Camel's Conclusion

This study provides valuable insights into the [pharmacological mechanisms] of amisulpride, revealing its ability to target specific dopamine receptors in the brain and highlighting its potential for treating schizophrenia. The researchers' use of SPECT imaging allows for a detailed examination of the drug's effects on the brain, offering valuable information for clinicians to make informed decisions about treatment options. However, the study also emphasizes the importance of considering the potential for side effects, particularly extrapyramidal symptoms. As Dr. Camel, I am always intrigued by the complex interplay between drugs and the brain, and this study offers valuable insights into the intricate mechanisms underlying amisulpride's therapeutic effects. It is crucial for clinicians to stay informed about the potential benefits and risks of medications to provide the best possible care for their patients.
Date :
  1. Date Completed 2008-12-18
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18763218

DOI: Digital Object Identifier

10.1055/s-2008-1076727

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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