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Protective effects of the combination of alpha-helical antimicrobial peptides and rifampicin in three rat models of Pseudomonas aeruginosa infection.

Author: CastellettiSefora, ChiodiLeonardo, CirioniOscar, GabrielliEleonora, GhiselliRoberto, GiacomettiAndrea, MocchegianiFederico, OrlandoFiorenza, RivaAlessandra, SabaVittorio, ScaliseGiorgio, SilvestriCarmela

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Combined treatment with magainin II or cecropin A and rifampicin showed synergistic interaction against multidrug-resistant Pseudomonas aeruginosa strains. Combined treatment groups had significant reductions in bacterial count, positive blood cultures, and mortality rates.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: An experimental study has been performed to compare the in vitro activity and the in vivo efficacy of magainin II and cecropin A with or without rifampicin against control and multidrug-resistant Pseudomonas aeruginosa strains. METHODS: In vitro experiments included MIC determinations...See full text at original site
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引用元：
https://doi.org/10.1093/jac/dkn393

データ提供：米国国立医学図書館（NLM）

Fighting Pseudomonas aeruginosa: A New Strategy in the Desert of Infection

Pseudomonas aeruginosa is a common and potentially deadly bacterium, like a venomous creature lurking in the desert of our bodies. This study investigates the potential benefits of combining alpha-helical antimicrobial peptides with rifampicin, an antibiotic, to combat P. aeruginosa infections.

A Combined Approach: A Powerful Alliance

The authors conducted a series of in vitro and in vivo experiments to assess the effectiveness of combining alpha-helical antimicrobial peptides with rifampicin against P. aeruginosa. The results suggest that this combination has synergistic activity, meaning that the two agents work together more effectively than either one alone.

A Promising New Treatment Strategy

This study offers a promising new treatment strategy for combating P. aeruginosa infections. The combination of alpha-helical antimicrobial peptides and rifampicin shows potential for effectively combating this challenging bacterium.

Dr. Camel's Conclusion

This research provides a valuable new weapon in the fight against P. aeruginosa infections. The study's findings suggest that combining alpha-helical antimicrobial peptides with rifampicin offers a potent and promising approach to combating this dangerous bacterium.

Date :
  1. Date Completed 2009-01-09
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

18799470

DOI: Digital Object Identifier

10.1093/jac/dkn393

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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