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Enhancement of glucose toxicity by hyperbaric oxygen exposure in diabetic rats.

Author: ManoYoshihiro, MatsunamiTokio, MorishimaTsunenori, SatoYukita, YukawaMasayoshi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effects of hyperbaric oxygen (HBO) treatment on glucose homeostasis and pancreatic beta-cells in diabetic rats. Results showed that HBO exposure enhanced the cytotoxic effect of streptozotocin (STZ) on beta-cells, indicating that HBO should be cautiously used in diabetic patients.
Paper Details　
Original Abstract of the Article :
The side effects of hyperbaric oxygen (HBO) treatment, such as oxidative stress and oxygen toxicity, have long been of interest. However, there are no comprehensive studies evaluating such toxic effects in diabetes mellitus (DM). The purpose of this study was to determine the effects of HBO on gluco...See full text at original site
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引用元：
https://doi.org/10.1620/tjem.216.127

データ提供：米国国立医学図書館（NLM）

Hyperbaric Oxygen: A Double-Edged Sword for Diabetics?

The field of [hyperbaric oxygen (HBO) therapy] is continually evolving, with new applications and potential benefits being explored. This study delves into the potential effects of HBO treatment on [glucose homeostasis] in diabetic rats. The authors investigated the impact of HBO on blood glucose levels and pancreatic beta-cell function, highlighting a potential interplay between HBO and diabetes mellitus.

A Complex Interaction: Hyperbaric Oxygen and Diabetes

The study's findings indicate that HBO exposure may exacerbate [glucose toxicity] in diabetic rats. The authors observed a significant increase in blood glucose levels and a reduction in insulin-producing beta-cell function in diabetic rats exposed to HBO. This suggests that HBO therapy should be used with caution in patients with diabetes.

Navigating the Desert of Diabetes: Hyperbaric Oxygen

This research provides a valuable reminder that even seemingly beneficial therapies can have unintended consequences. The study underscores the importance of carefully considering the individual patient's medical history and potential risks before initiating HBO therapy, particularly in individuals with diabetes.

Dr. Camel's Conclusion

Like a camel traversing a harsh desert, diabetic patients face unique challenges in managing their condition. This study reminds us that even seemingly beneficial therapies, like HBO, can have unintended consequences. By carefully considering the potential risks and benefits, we can strive to provide safe and effective treatment strategies for diabetic patients.

Date :
  1. Date Completed 2009-02-20
  2. Date Revised 2019-07-27
Further Info :

Pubmed ID

18832794

DOI: Digital Object Identifier

10.1620/tjem.216.127

Related Literature

Article Analysis
・Side Effects of streptozocin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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