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Suppression of dopamine-related side effects of morphine by aripiprazole, a dopamine system stabilizer.

Author: AmanoTaku, AsatoMegumi, HashimotoKeisuke, IkegamiDaigo, KuzumakiNaoko, MatsushimaYuki, NakamuraAtsushi, NaritaMichiko, NaritaMinoru, NiikuraKeiichi, ShiokawaMitsuru, SuzukiTsutomu, TakagiShigemi, TakeiDaisuke, TsurukawaYuri

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Aripiprazole, a dopamine system stabilizer, was found to suppress morphine-induced hyperlocomotion, reward, and dopamine levels in the nucleus accumbens in mice. This suggests aripiprazole could be useful in mitigating morphine-induced dopamine-related side effects.
Paper Details　
Original Abstract of the Article :
Dopamine receptor antagonists are commonly used to counter the adverse effects of opioids such as hallucinations, delusions and emesis. However, most of these agents themselves have side effects, including extrapyramidal symptoms. Here, we investigated the effect of the dopamine system stabilizer ar...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2008.10.030

データ提供：米国国立医学図書館（NLM）

Aripiprazole: A Potential Solution to Morphine-Induced Side Effects

This research investigates the potential of aripiprazole, a dopamine system stabilizer, to mitigate the dopamine-related side effects associated with morphine use. The study, using a mouse model, compared the effects of aripiprazole to those of a conventional dopamine receptor antagonist, prochlorperazine. The results suggest that aripiprazole could offer a safer and more effective approach to managing these side effects.

Aripiprazole: A Balancing Act for Morphine Side Effects

Aripiprazole effectively suppressed morphine-induced hyperlocomotion and reward, indicating its ability to manage the stimulant effects of morphine. Crucially, aripiprazole did not induce catalepsy, a side effect often associated with conventional dopamine receptor antagonists. This suggests that aripiprazole might be a more tolerable option for patients requiring morphine.

Navigating Morphine's Side Effects

This research offers a potential avenue for addressing a common concern associated with morphine use. By exploring the role of aripiprazole in managing dopamine-related side effects, the study contributes to a safer and more manageable therapeutic experience for patients requiring opioid pain relief.

Dr. Camel's Conclusion

This study provides a valuable contribution to the quest for safer and more effective pain management strategies. The findings suggest that aripiprazole could play a key role in mitigating the side effects of morphine, potentially leading to a more comfortable and well-tolerated therapeutic experience for patients. It’s like finding a cool spring of relief in the desert of morphine-induced side effects.
Date :
  1. Date Completed 2009-03-27
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

18955042

DOI: Digital Object Identifier

10.1016/j.ejphar.2008.10.030

SNS
PICO Info
in preparation
Languages

English

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