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Transmucosal gastric leak induced by proton pump inhibitors.

Author: FarrellChristopher P, GabelloMelissa, MartinAaron P, MorganMelissa, MullinJames M, MurrayLisa J, RudolphDavid S, UnderwoodJames C, ValenzanoM Carmen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Proton pump inhibitors (PPIs), despite their safety profile, induce a transmucosal gastric leak in rats. The study found that PPIs increased transmucosal permeability in a dose-dependent manner, suggesting potential biomedical implications for their widespread use.
Paper Details　
Original Abstract of the Article :
Despite their remarkable safety profile and lack of clinical side effects, proton pump inhibitors (PPIs) induce a transmucosal gastric leak to non-electrolyte probes of various sizes. The ex vivo addition of PPIs to isolated rat gastric corpus increases transmucosal permeability in a dose-dependent ...See full text at original site
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引用元：
https://doi.org/10.1007/s10620-008-0528-z

データ提供：米国国立医学図書館（NLM）

Proton Pump Inhibitors: A Hidden Side Effect

As we delve deeper into the desert of [pharmacology], we often uncover unexpected truths. This study examines the potential side effects of proton pump inhibitors (PPIs), commonly used medications for acid reflux.

A Transmucosal Gastric Leak: An Unexpected Finding

The research reveals a surprising effect of PPIs—they induce a transmucosal gastric leak. This leak allows non-electrolyte probes of various sizes to pass through the gastric mucosa, which could have significant implications for overall health.

The Importance of Understanding Drug Side Effects

This study underscores the importance of continuous research into the potential side effects of even seemingly harmless medications. The findings highlight the need for ongoing vigilance and a thorough understanding of the complexities of drug interactions within the body.

Dr.Camel's Conclusion

In the vast desert of [medicine], we must be mindful of the unexpected. This research demonstrates that even widely used medications can have hidden side effects. As we continue to explore the intricacies of drug interactions, it is crucial to maintain a critical eye and a thirst for knowledge.
Date :
  1. Date Completed 2009-07-15
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19015985

DOI: Digital Object Identifier

10.1007/s10620-008-0528-z

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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