The impact of calories and fat content of meals on oral ziprasidone absorption: a randomized, open-label, crossover trial.

Author: AldermanJeffrey A, GandelmanKuan, GluePaul, LaBadieRobert R, LombardoIlise, PreskornSheldon H, VersavelMark

Paper Details 
Original Abstract of the Article :
Food is known to increase the bioavailability of ziprasidone. Therefore, we evaluated the effects of meals of differing caloric and fat content on steady-state ziprasidone exposure in a stable, treated group of subjects with DSM-IV diagnoses of schizophrenia, schizoaffective disorder, bipolar disord...See full text at original site
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引用元:
https://doi.org/10.4088/jcp.08m04104

データ提供:米国国立医学図書館(NLM)

Food and Ziprasidone Absorption: A Study in Meal-Related Pharmacokinetics

This study explores the impact of food on the absorption of ziprasidone, an antipsychotic medication. The researchers conducted a randomized, open-label, crossover trial to investigate the effects of meals with varying caloric and fat content on steady-state ziprasidone exposure in patients with schizophrenia, schizoaffective disorder, bipolar disorder, or psychotic disorder. The findings demonstrate that food significantly increases the bioavailability of ziprasidone. The study highlights the importance of considering meal timing and composition when prescribing ziprasidone to ensure optimal drug absorption and therapeutic efficacy.

Meal Timing and Ziprasidone Absorption: A Key Factor in Drug Effectiveness

The study underscores the importance of meal timing and composition in optimizing ziprasidone absorption. The researchers' findings highlight the significant impact of food on the bioavailability of this medication, emphasizing the need for careful consideration of these factors in clinical practice.

Optimizing Medication Therapy: The Role of Food and Drug Interactions

This research emphasizes the crucial role of food-drug interactions in optimizing medication therapy. The study's findings provide valuable insights into the impact of food on ziprasidone absorption, highlighting the importance of individualized approaches to medication management to ensure optimal patient outcomes.

Dr.Camel's Conclusion

This study, like a camel carefully navigating a sandy path, highlights the importance of understanding the interplay between food and medication. The researchers' findings shed light on the impact of meals on ziprasidone absorption, underscoring the need for careful consideration of these factors in clinical practice.
Date :
  1. Date Completed 2009-03-05
  2. Date Revised 2019-09-02
Further Info :

Pubmed ID

19026256

DOI: Digital Object Identifier

10.4088/jcp.08m04104

Related Literature

SNS
PICO Info
in preparation
Languages

English

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