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Muscarinic receptor antagonists for overactive bladder treatment: does one fit all?

Author: MichelMartin C, MulderWilhemina M C, WitteLambertus P W, de la RosetteJean J M C H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Muscarinic receptor antagonists used for overactive bladder may cause greater exposure and side effects in patients with renal impairment, hepatic impairment, or genetic predisposition. Physicians should be aware of these potential risks and adjust dosing accordingly.
Paper Details　
Original Abstract of the Article :
PURPOSE OF REVIEW: To review evidence and regulatory dosing recommendations for muscarinic receptor antagonists used in the treatment of overactive bladder symptom complex (darifenacin, fesoterodine, oxybutynin, propiverine, solifenacin, tolterodine, trospium) in special patient populations. RECENT...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19057211

データ提供：米国国立医学図書館（NLM）

Muscarinic Receptor Antagonists: A Personalized Approach to Overactive Bladder

The journey through the desert of overactive bladder can be fraught with discomfort and social anxiety. Muscarinic receptor antagonists, a class of medications used to treat this condition, work by calming the bladder muscles. This research delves into the nuances of using these medications in different patient populations, highlighting the importance of personalized treatment approaches.

Tailoring Treatment: A Crucial Step

This research emphasizes the need for a personalized approach to treating overactive bladder. It's like tailoring a camel's saddle to fit its unique back - understanding the individual needs of each patient is crucial for optimal treatment outcomes. The researchers explore the effects of factors such as renal impairment, hepatic impairment, and genetics on the efficacy of these medications.

Navigating the Desert of Pharmacokinetic Variability

This research highlights the importance of considering individual pharmacokinetic profiles when prescribing muscarinic receptor antagonists. It's like navigating a desert with shifting sands – understanding the unique dynamics of each patient's body is vital for ensuring a safe and effective treatment journey.

Dr.Camel's Conclusion

Treating overactive bladder requires a personalized approach, like customizing a camel's pack to fit its unique needs. This research emphasizes the importance of considering factors such as renal and hepatic function, genetics, and comedications to ensure optimal treatment outcomes and minimize potential side effects.

Date :
  1. Date Completed 2009-03-25
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

19057211

DOI: Digital Object Identifier

00042307-200901000-00005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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