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Effects of endurance exercise on ventral tegmental area neurons in the chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and probenecid-treated mice.

Author: AhmadS Omar, LauYuen-Sum, ParkJi-Hyuk, Stenho-BittelLisa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Exercise training is neuroprotective for dopaminergic neurons in the VTA in a chronic mouse model of Parkinson's disease with moderate neurodegeneration. 18 weeks of exercise restored the number of VTA neurons to a normal range.
Paper Details　
Original Abstract of the Article :
Loss of dopaminergic neurons in the substantia nigra (A9 cells) and ventral tegmental area (VTA) (A10 cells) has been reported in Parkinson's disease with reference to causing motor and non-motor deficits, although clinical and laboratory animal studies on the degeneration of VTA neurons are less em...See full text at original site
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引用元：
https://doi.org/10.1016/j.neulet.2008.11.065

データ提供：米国国立医学図書館（NLM）

Endurance Exercise: A Potential Remedy for Parkinson's Disease

The study of Parkinson's disease (PD) is a journey through the intricate pathways of the brain, seeking solutions to alleviate the debilitating symptoms of this neurodegenerative disorder. In this research, we follow researchers as they explore the potential neuroprotective effects of endurance exercise on the dopaminergic neurons in the ventral tegmental area (VTA), a brain region critically involved in motor control and reward. They investigate the impact of endurance exercise on a mouse model of Parkinson's disease, focusing on the potential to mitigate the loss of dopaminergic neurons in the VTA.

Endurance Exercise: A Beacon of Hope for Parkinson's Disease

The results reveal that endurance exercise appears to be neuroprotective for the dopaminergic neurons in the VTA in this Parkinson's disease model. This suggests that exercise could potentially play a role in mitigating the progression of PD, offering a glimmer of hope for individuals affected by this debilitating disease.

Exercise: A Journey Through the Desert of Parkinson's

This study points to the potential benefits of incorporating endurance exercise into the lives of those living with Parkinson's disease. It suggests that exercise can serve as a valuable tool in managing the progression of this disorder. However, it is important to emphasize that each individual's journey through the desert of Parkinson's is unique, requiring personalized approaches to care and treatment.

Dr.Camel's Conclusion

Endurance exercise offers a glimmer of hope in the desert of Parkinson's disease. Its potential neuroprotective effects on the VTA region hold promise for mitigating the progression of this disorder. Remember, every journey through this desert is unique, requiring a personalized approach to care and treatment, guided by healthcare professionals.

Date :
  1. Date Completed 2009-03-24
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19084578

DOI: Digital Object Identifier

10.1016/j.neulet.2008.11.065

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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