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The effects of normal aging on the response of the pituitary-gonadal axis to chronic clomiphene administration in men.

Author: BremnerW J, TenoverJ S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Elderly men showed a diminished testicular response to gonadotropin stimulation compared to young adult men, indicating a decline in testicular function with age.
Paper Details　
Original Abstract of the Article :
Serum androgens decline with age in normal men, despite normal or elevated bioactive serum gonadotropins, suggesting that primary testicular dysfunction occurs with aging. The authors further assessed the question of age-related testicular dysfunction by evaluating whether raising serum gonadotropin...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1917692

データ提供：米国国立医学図書館（NLM）

Aging and Testicular Function: Exploring the Effects of Clomiphene

This research explores the effects of aging on the pituitary-gonadal axis in men, particularly in response to chronic clomiphene administration. The researchers used a [research methodology] to compare the responses of young adult men and elderly men to clomiphene citrate (CC) administration over an eight-week period. The results reveal that aging significantly diminishes the testicular response to gonadotropin stimulation, highlighting the age-related decline in testicular function.

Testicular Function and Aging: A Complex Relationship

The findings of this study underscore the complexity of the aging process and its impact on various bodily systems, including the reproductive system. The diminished response of the testes to gonadotropin stimulation in elderly men underscores the need for tailored treatment strategies to address age-related changes in hormone levels.

Maintaining Reproductive Health as We Age

Understanding the age-related decline in testicular function is crucial for maintaining reproductive health as we age. While some changes are inevitable, healthy lifestyle choices, regular medical checkups, and consulting with healthcare professionals can help manage these changes and promote overall well-being.

Dr.Camel's Conclusion

As the desert sands shift and time marches on, so too do the processes within our bodies. This research, like a weathered traveler navigating the desert's changing landscape, reveals the impact of aging on testicular function. While age-related changes are inevitable, understanding these shifts allows us to adapt, seek support, and maintain our health as we continue our journey through life.

Date :
  1. Date Completed 1991-11-04
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

1917692

DOI: Digital Object Identifier

1917692

Related Literature

Article Analysis
・Effects of clomiphene
SNS
PICO Info
in preparation
Languages

English

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