Efficacy and safety of deferasirox, an oral iron chelator, in heavily iron-overloaded patients with beta-thalassaemia: the ESCALATOR study.

Author: Al JefriAbdullah, Al ZirKusai, DaarShahina, El-BeshlawyAmal, ElalfyMohsen S, HabrDany, HmissiAbdel, Kriemler-KrahnUlrike, TaherAli

Paper Details 
Original Abstract of the Article :
Many patients with transfusional iron overload are at risk for progressive organ dysfunction and early death and poor compliance with older chelation therapies is believed to be a major contributing factor. Phase II/III studies have shown that oral deferasirox 20-30 mg/kg/d reduces iron burden, depe...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730551/

データ提供:米国国立医学図書館(NLM)

Deferasirox: A Promising Oral Iron Chelator for Beta-Thalassaemia

This study investigates the efficacy and safety of deferasirox, an oral iron chelator, in treating transfusional iron overload in patients with beta-thalassaemia, a genetic blood disorder that leads to iron accumulation in the body. The study aimed to evaluate the effectiveness of deferasirox in reducing iron burden and improving outcomes in patients with severe iron overload.

The study found that deferasirox was effective in reducing iron burden in patients with severe iron overload, demonstrating a dose-dependent response. The researchers found that deferasirox was well-tolerated by patients, with a favorable safety profile. The study concluded that deferasirox is a promising new treatment option for patients with beta-thalassaemia and severe iron overload, offering an effective and well-tolerated alternative to existing chelation therapies. The study also highlighted the potential benefits of deferasirox in improving patient compliance with chelation therapy, as its oral administration provides a more convenient and flexible treatment option.

Iron Overload in Beta-Thalassaemia: A Complex Challenge

Beta-thalassaemia is a challenging condition, and managing iron overload is a crucial aspect of patient care. This study highlights the potential of deferasirox as a safe and effective treatment option for patients with severe iron overload. It's like discovering a new oasis in the desert, offering a refreshing source of hope for individuals facing this complex health challenge.

Improving Treatment Options for Beta-Thalassaemia

Beta-thalassaemia is a chronic condition requiring ongoing management. This study offers valuable insights into the potential of deferasirox to improve treatment outcomes for patients with iron overload. It's like finding a new route through the desert, offering a smoother and more efficient path to managing this complex condition. The study emphasizes the importance of continued research and development to improve treatment options and enhance the quality of life for individuals with beta-thalassaemia.

Dr.Camel's Conclusion

This study offers a promising new approach to managing iron overload in patients with beta-thalassaemia. It's like discovering a hidden spring in the desert, providing a refreshing source of hope for individuals struggling with this condition. The findings underscore the importance of continued research and development to find better treatments for beta-thalassaemia and improve the lives of patients.

Date :
  1. Date Completed 2009-05-27
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19187278

DOI: Digital Object Identifier

PMC2730551

Related Literature

SNS
PICO Info
in preparation
Languages

English

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