Effects of dexlansoprazole MR, a novel dual delayed release formulation of a proton pump inhibitor, on plasma gastrin levels in healthy subjects.

Author: AtkinsonStuart N, WuJingtao, ZhangWeijiang

Paper Details 
Original Abstract of the Article :
Dexlansoprazole MR is a modified release formulation of a proton pump inhibitor being developed for the treatment of acid-related disorders. The purpose of this study is to characterize the plasma gastrin (PG) profile associated with administration of dexlansoprazole MR. Forty-two healthy subjects r...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1177/0091270008330155

データ提供:米国国立医学図書館(NLM)

Dexlansoprazole MR: A Novel Approach to Acid-Related Disorders

The digestive system, a complex and intricate network of organs, is responsible for breaking down food and absorbing nutrients. However, sometimes this process can go awry, leading to acid-related disorders such as heartburn and indigestion. This research explores the effects of dexlansoprazole MR, a novel dual delayed release formulation of a proton pump inhibitor, on plasma gastrin levels in healthy subjects. The authors aim to understand the impact of this medication on the body's natural regulatory mechanisms, seeking to optimize its use for treating acid-related disorders.

Navigating the Tides of Gastrin Levels

The study examines the effects of dexlansoprazole MR on plasma gastrin levels, a hormone that plays a crucial role in regulating stomach acid production. The authors found that dexlansoprazole MR administration resulted in moderate increases in gastrin levels, similar to the effects of lansoprazole, a commonly used proton pump inhibitor. However, these elevated levels returned to baseline within 7 days of stopping the medication.

A Balanced Approach to Digestive Health

Maintaining a healthy digestive system requires a balanced approach that encompasses dietary choices, lifestyle habits, and, when necessary, medication. This research provides valuable insights into the effects of dexlansoprazole MR on the body's regulatory mechanisms, helping to inform clinical decision-making. By working closely with healthcare professionals, individuals can make informed choices to address acid-related disorders and promote overall digestive well-being.

Dr. Camel's Conclusion

This research offers a fascinating glimpse into the world of digestive health, revealing the delicate interplay of hormones and medications in regulating stomach acid production. Just as a desert oasis must carefully manage its precious water resources, our bodies must maintain a balance of digestive chemicals to function optimally. This research helps us understand the impact of dexlansoprazole MR on this delicate equilibrium, providing valuable insights for treating acid-related disorders and promoting a healthy digestive system.

Date :
  1. Date Completed 2009-06-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19318694

DOI: Digital Object Identifier

10.1177/0091270008330155

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.