Atypical Takotsubo syndrome during anagrelide therapy.

Author: ArdizzoneFabio, MaccioSergio, ProiettiRiccardo, RognoniAndrea, RognoniGiorgio, SantagostinoAlberto

Paper Details 
Original Abstract of the Article :
Anagrelide is a phosphodiesterase III inhibitor utilized in the treatment of essential thrombocythemia. Anagrelide can be responsible for positive inotropic and chonotropic activity of the cardiovascular system. Moreover, it can induce vasospam directly on the epicardial coronary arteries. In the li...See full text at original site
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引用元:
https://doi.org/10.2459/JCM.0b013e32832b7f08

データ提供:米国国立医学図書館(NLM)

Anagrelide and Takotsubo Syndrome: An Unexpected Connection

Anagrelide is a medication used to treat essential thrombocythemia, a blood disorder characterized by high platelet counts. This research reports a case of a 75-year-old woman who developed Takotsubo syndrome, also known as "broken heart syndrome," while on anagrelide therapy. Takotsubo syndrome is a temporary heart condition that mimics a heart attack, but without coronary artery blockage. The authors suggest that anagrelide's inotropic and chonotropic effects, combined with its potential to induce coronary artery spasm, may have contributed to the development of Takotsubo syndrome in this patient.

Anagrelide and Takotsubo Syndrome: A Cautionary Tale

This case report highlights the potential for anagrelide therapy to induce Takotsubo syndrome. While this is a rare occurrence, it emphasizes the importance of careful monitoring for cardiovascular complications in patients receiving anagrelide. Healthcare professionals should be aware of this potential association and promptly investigate any symptoms suggestive of Takotsubo syndrome.

Staying Vigilant: Understanding Potential Side Effects

It is crucial to be aware of potential side effects associated with any medication, especially those that affect the cardiovascular system. If you are taking anagrelide, be sure to discuss any unusual symptoms with your doctor promptly. Early detection and intervention are critical for managing potential complications and ensuring your overall health and well-being.

Dr.Camel's Conclusion

Just as a camel can become weary after a long journey through the desert, the heart can also experience stress and strain. This case report serves as a reminder that even seemingly unrelated medications can have unexpected effects on the cardiovascular system. It's a reminder to stay vigilant, communicate openly with your healthcare provider, and prioritize your heart health.

Date :
  1. Date Completed 2009-07-17
  2. Date Revised 2016-11-25
Further Info :

Pubmed ID

19395976

DOI: Digital Object Identifier

10.2459/JCM.0b013e32832b7f08

Related Literature

SNS
PICO Info
in preparation
Languages

English

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