Paper Details

  1. Home
  2. Paper Details

Effects of fenbendazole on the murine humoral immune system.

Author: AltmanNorman H, BlombergBonnie B, FrascaDaniela, LandinAna Marie, RileyRichard L, Van der PutElaine, ZaiasJulia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Fenbendazole (FBZ) treatment, while effective against pinworms in mice, can negatively impact the immune system, especially in aged mice. FBZ treatment significantly affected B lymphocyte function and expression of E2A, a crucial transcription factor. These effects were reversible but delayed, suggesting researchers should consider waiting at least 6 weeks after treatment before using mice in experiments.
Paper Details　
Original Abstract of the Article :
Pinworms are highly contagious parasites that have been effectively treated in laboratory rodents with fenbendazole (FBZ). Whether FBZ has any detrimental side effects that may compromise experimental results is unknown. Here we asked whether the immune systems from young and aged mice are altered u...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696826/

データ提供：米国国立医学図書館（NLM）

Fenbendazole: A Potential Immune System Disruptor

Fenbendazole (FBZ) is a medication used to treat pinworms, but its potential side effects on the immune system remain unclear. This study explores the impact of FBZ on the immune system of mice, focusing on both young and aged individuals. It's like studying the effects of a new type of sandstorm on the delicate balance of the desert ecosystem – understanding how FBZ could potentially disrupt the natural processes of the immune system.

FBZ Alters Immune Function in Mice

The study reveals that FBZ treatment can significantly affect the immune system of mice, particularly in aged individuals. These findings suggest that FBZ may have unintended consequences for the immune system. It's like the sandstorm changing the landscape of the desert, affecting the growth of plants and the behavior of animals.

Weighing the Benefits and Risks

This study underscores the importance of carefully considering the potential risks and benefits of FBZ treatment. It's like navigating a treacherous desert path – you need to be aware of potential hazards and weigh the risks against the rewards.

Dr.Camel's Conclusion

This study highlights the potential impact of FBZ on the immune system, especially in older individuals. It's like discovering a hidden, unexpected danger lurking in the sand dunes. While FBZ can be effective in treating pinworms, it's important to be aware of its potential effects and to carefully consider the implications for the overall health of the individual.

Date :
  1. Date Completed 2009-07-16
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19476712

DOI: Digital Object Identifier

PMC2696826

Related Literature

Article Analysis
・Effective treatment of pinworms
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.