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Pharmacological characterization of harmaline-induced tremor activity in mice.
Author: ForemanMark M, HananiaTaleen, MalekianiSam A, OlivierBerend, PatersonNeil E
Original Abstract of the Article :
Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor activity was dependent on harmaline dose. The first-line clinical essential tremor treatments propranolol, primidone and gabapentin and gamma-hydrox...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1016/j.ejphar.2009.05.031
データ提供:米国国立医学図書館(NLM)
Unlocking the Secrets of Essential Tremor: A Model in the Desert of Neurological Research
Essential tremor, like a shaking mirage in the desert, can make everyday life challenging. This study, like a group of researchers carefully mapping a desert terrain, investigated the mechanisms of essential tremor using a model induced by harmaline in mice. They explored the effects of various medications on tremor activity, seeking to unravel the underlying neurological pathways.
Unveiling the Neurological Pathways
The study, like an explorer uncovering hidden pathways, revealed that harmaline-induced tremor in mice was responsive to various drugs, including those used to treat essential tremor in humans, such as propranolol, primidone, and gabapentin. The study also demonstrated the involvement of several neurotransmitter systems, including GABA, glutamate, and dopamine, in the development of tremor activity.
Understanding and Treating Essential Tremor
The desert of neurological research is vast and intricate. This study, like a beacon of light in the darkness, provides valuable insights into the mechanisms of essential tremor. By understanding the role of specific neurotransmitter systems, researchers can develop more effective treatments for this debilitating condition.
Dr.Camel's Conclusion
This study, like a camel caravan searching for a hidden spring, offers a glimpse into the complex neurological pathways involved in essential tremor. The findings, like a refreshing oasis, highlight the potential for developing novel therapies for this condition. Continued research, like exploring the vastness of the desert, is essential to discover new pathways toward a brighter future for those living with essential tremor.
Date :
- Date Completed 2009-10-19
- Date Revised 2022-04-10
Further Info :
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English
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