Paper Details 
Original Abstract of the Article :
The term "Epigenetics" refers to DNA and chromatin modifications that persist from one cell division to the next, despite a lack of change in the underlying DNA sequence. The "epigenome" refers to the overall epigenetic state of a cell, and serves as an interface between the environment and the geno...See full text at original site
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引用元:
https://doi.org/10.1016/j.mehy.2008.10.039

データ提供:米国国立医学図書館(NLM)

Epigenetic Side-Effects: A New Frontier in Pharmacology

The world of medicine is constantly evolving, with new discoveries and advancements emerging to combat the challenges of disease. This study explores a fascinating new frontier in pharmacology: the potential epigenetic side-effects of commonly used pharmaceutical drugs.

The authors delve into the intricate world of epigenetics, a field that explores the mechanisms by which environmental factors can influence gene expression without altering the underlying DNA sequence. They propose that commonly used drugs can cause persistent epigenetic changes, impacting gene expression long after the drug has been discontinued.

The study suggests that these epigenetic changes may contribute to the development of a range of chronic diseases, including heart disease, cancer, neurological and cognitive disorders, obesity, diabetes, infertility, and sexual dysfunction. This groundbreaking hypothesis calls for a paradigm shift in the way we understand drug safety and efficacy, emphasizing the need for long-term studies that assess epigenetic changes in response to drug exposure.

Epigenetic Side-Effects: A New Frontier in Pharmacology

This study opens up a fascinating new chapter in pharmacology, highlighting the potential for epigenetic side-effects of commonly used drugs. The findings suggest that epigenetic changes may play a role in the development of a range of chronic diseases, calling for a paradigm shift in our understanding of drug safety and efficacy.

Epigenetics: A New Lens for Understanding Drug Effects

This study underscores the importance of considering epigenetic changes when assessing the long-term effects of drugs. The potential for drugs to alter the epigenome has profound implications for understanding drug safety and efficacy, and highlights the need for further research into the long-term consequences of drug exposure.

Dr. Camel's Conclusion

This study delves into the fascinating world of epigenetics and its potential impact on drug safety and efficacy. It highlights the need for a paradigm shift in our understanding of drug effects, emphasizing the importance of long-term studies that assess epigenetic changes in response to drug exposure.

Date :
  1. Date Completed 2010-01-04
  2. Date Revised 2009-10-13
Further Info :

Pubmed ID

19501473

DOI: Digital Object Identifier

10.1016/j.mehy.2008.10.039

Related Literature

SNS
PICO Info
in preparation
Languages

English

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